Long-term outcomes of invasive thymoma treated with brachytherapy Journal Article
| Authors: | Allen, L. F. H.; Sidebotham, H.; Bains, M.; Zelefsky, M. J. |
| Article Title: | Long-term outcomes of invasive thymoma treated with brachytherapy |
| Abstract: | The purpose of this study was to report the long-term results of patients with invasive thymoma treated with brachytherapy as part of their management. Sixteen patients with invasive thymoma underwent resection and brachytherapy at Memorial Sloan-Kettering Cancer Center, New York, NY. Nine patients (56%) presented with primary stage III disease, and seven (44%) presented with recurrent disease. These 16 patients had 22 implanted sites, 19 (86%) with permanent iodine-125, two (9%) with low dose rate iridium-192, and one (5%) with high dose rate 192Ir intraoperative radiation therapy. Five patients had complete resection with negative margins, five had positive margins, and six had gross residual disease. All patients received adjuvant external beam radiation therapy (EBRT), pre- or postoperatively (median dose, 40 and 45 Gy, respectively). Eight patients received preoperative, cisplatin- based chemotherapy. The median follow-up time was 71 months. No failures occurred at the implanted site. There were three mediastinal relapses, for a ten-year actuarial locoregional control rate of 68%. The ten-year actuarial distant metastases-free, disease-free, and overall survival rates were 49%, 50%, and 50%, respectively. Neither stage of disease nor histologic appearance affected survival. Survival rates were significantly improved in patients undergoing complete resection compared with subtotal resection (100% vs 53%, P=.04). Complications included one postoperative death as a result of sepsis, one fistula, and one case of cor pulmonale. Brachytherapy combined with EBRT for stage III or recurrent invasive thymoma after resection provides excellent local control without significant added morbidity. |
| Keywords: | adult; cancer chemotherapy; clinical article; treatment outcome; aged; survival rate; treatment failure; cancer recurrence; cisplatin; radiation dose; recurrence risk; cancer invasion; cancer regression; iodine 125; long term care; brachytherapy; thymoma; iridium 192; invasive thymoma; beam therapy; human; male; female; priority journal; article |
| Journal Title: | Journal of Brachytherapy International |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 1094-4540 |
| Publisher: | Endocurietherapy Research Foundation |
| Date Published: | 1999-01-01 |
| Start Page: | 43 |
| End Page: | 49 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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