Histologic predictors of survival in acquired immunodeficiency syndrome-associated Kaposi's sarcoma Journal Article
| Authors: | Niedt, G. W.; Myskowski, P. L.; Urmacher, C.; Niedzwiecki, D.; Chapman, D.; Krown, S. E.; Safai, B. |
| Article Title: | Histologic predictors of survival in acquired immunodeficiency syndrome-associated Kaposi's sarcoma |
| Abstract: | The relationship between 22 histologic variables and survival was investigated in 93 patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS). All the patients were homosexual men in whom KS was the initial manifestation of AIDS. All patients were followed for at least 12 months or until death. Histologic specimens of the initial KS biopsy were reviewed in a blind manner by two of the authors and were evaluated for the presence of a number of histologic features. In a univariate analysis nodular lesions of KS (v patch or plaque lesions), the absence of hemosiderin, the absence of irregular vascular spaces, and the presence of spindle cell nodules were all significantly associated with increased length of survival. Two variables previously shown to be related to survival (CD4:CD8 cell ratio, initial lesion on lower extremities) were included in a multivariate analysis (Cox model) in addition to the histologic variables. Complete data were avaiable from 85 patients. In the multivariate analysis a higher helper to suppressor T-cell ratio, initial lesion on lower extremities, presence of spindle cell nodules, and nodular histology (v patch or plaque histology) were all significantly associated with increased length of survival. These data suggest that in AIDS-associated KS, as in reticuloendothelial neoplasms, histologic features may be useful in idenitifying prognostically different subgroups of patients. © 1992. |
| Keywords: | adult; human tissue; retrospective studies; clinical feature; lymph nodes; cd8 antigen; skin biopsy; survival time; predictive value of tests; homosexuality; multivariate analysis; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; sarcoma, kaposi; cd4 antigen; suppressor cell; helper cell; opportunistic infection; middle age; hemosiderin; cd4-cd8 ratio; prognosis; human; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Human Pathology |
| Volume: | 23 |
| Issue: | 12 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1992-12-01 |
| Start Page: | 1419 |
| End Page: | 1426 |
| Language: | English |
| DOI: | 10.1016/0046-8177(92)90063-9 |
| PUBMED: | 1468779 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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