Negative regulators of growth Journal Article
| Authors: | Massagué, J.; Weinberg, R. A. |
| Article Title: | Negative regulators of growth |
| Abstract: | The proliferation of cells is regulated by countervailing positively- and negatively-acting signaling networks. The anti-proliferative signals, the study of which has been much neglected until recently, are often conveyed by growth-inhibitory peptides. Elements that mediate the cellular response to growth inhibitors are encoded by tumor suppressor genes that if lost may lead to the runaway growth of the cancer cell. © 1992 Current Biology Ltd. |
| Keywords: | signal transduction; genetics; review; transforming growth factor beta; retinoblastoma; tumor suppressor gene; genes, tumor suppressor; rb; nf1; growth inhibitor; growth inhibitors; adenomatous polyposis coli; neurofibromatosis type 1; igf; adc; nerve growth factor; insulin-like growth factor; mis; wilms' tumor; loh; dcc; deleted in colon carcinoma; loss of heterzygosity; müllerian inhibiting substance; ngf; wt |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 1992-02-01 |
| Start Page: | 28 |
| End Page: | 32 |
| Language: | English |
| DOI: | 10.1016/s0959-437x(05)80317-x |
| PUBMED: | 1633423 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
