The relationship between thallium uptake, blood flow, and blood pool activity in bone and soft tissue tumors Journal Article

  


Authors: Caluser, C.; Macapinlac, H.; Healey, J.; Ghavimi, F.; Meyers, P.; Wollner, N.; Kalaigian, J.; Kostakoglu, L.; Abdel-Dayem, H. M.; Yeh, S. D. J.; Larson, S. M.
Article Title: The relationship between thallium uptake, blood flow, and blood pool activity in bone and soft tissue tumors
Abstract: Twenty patients with known primary untreated and recurrent bone and soft tissue tumors underwent thallium imaging and three-phase bone imaging in the same session. The ratio of thallium uptake in the tumor tissue to the contralateral normal tissue areas was compared with the same ratio for phase 1 (blood flow or arterial phase), phase 2 (blood pool), and phase 3 (delayed medroxydiphosphonate, MDP, uptake). There was poor correlation between TI uptake and phases 1 and 3 of the bone scan ratios; r = 0.37 and 0.46; P = 0.097 and 0.047, respectively. The thallium uptake ratios correlated well with blood pool ratios (phase 2) (r = 0.84 and P < 0.01). In contrast to uptake into normal muscle, TI-201 uptake into tumor is not highly dependent on blood flow alone and other factors predominate in determining its magnitude.
Keywords: clinical article; bone neoplasms; time factors; medronate technetium tc 99m; soft tissue neoplasms; thallium 201; intravenous drug administration; bone scintiscanning; bone cancer; thallium radioisotopes; whole body scintiscanning; technetium tc 99m medronate; soft tissue cancer; human; male; female; article
Journal Title: Clinical Nuclear Medicine
Volume: 17
Issue: 7
ISSN: 0363-9762
Publisher: Lippincott Williams & Wilkins  
Date Published: 1992-07-01
Start Page: 565
End Page: 572
Language: English
DOI: 10.1097/00003072-199207000-00007
PUBMED: 1638838
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026685687&doi=10.1097%2f00003072-199207000-00007&partnerID=40&md5=ae4c0f18df3c79712ec251eb4ea10ac6
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. Samuel D J Yeh
    107 Yeh
  2. Homer Macapinlac
    106 Macapinlac
  3. Steven M Larson
    958 Larson
  4. Paul Meyers
    311 Meyers
  5. John H Healey
    547 Healey
  6. John P Kalaigian
    6 Kalaigian
  7. Norma Wollner Sternberg
    40 Wollner Sternberg
  8. Fereshteh Ghavimi
    30 Ghavimi
  9. Lale Kostakoglu
    22 Kostakoglu
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