Correlation of the findings of thallium-201 chloride scans with those of other imaging modalities and histology following therapy in patients with bone and soft tissue sarcomas Journal Article

  

Authors:	Kostakoglu, L.; Panicek, D. M.; Divgi, C. R.; Botet, J.; Healy, J.; Larson, S. M.; Abdel-Dayem, H. M.
Article Title:	Correlation of the findings of thallium-201 chloride scans with those of other imaging modalities and histology following therapy in patients with bone and soft tissue sarcomas
Abstract:	We performed a prospective study to evaluate the imaging potential of thallium-201 as compared with other imaging modalities in differentiating residual/re-current tumors from post-therapy changes in patients with musculoskeletal sarcomas.201TI scans, magnetic resonance imaging (17), X-ray computed tomography (6) or contrast angiography (6) studies in 29 patients previously treated for musculoskeletal sarcomas were correlated with either histopathologic findings (26 patients) or 2-year clinical follow-up (three patients). All imaging studies were acquired within 2 weeks. Ratios of201T1 tumor uptake to the contralateral (28 patients) or adjacent region of interest were calculated. When qualitative interpretation was in doubt, only those cases with a ratio of 1.5 or more were considered suggestive of recurrent or residual viable tumor tissue. Residual or recurrent tumor tissue was verified in 21 patients by biopsy. All had true-positive201Tl scans while the other imaging modalities were true-positive in 20 and equivocal in one. In eight patients, there was no evidence of viable tumor tissue as proven by biopsy in five and long-term clinical follow-up in three.201Tl scan was false-positive (ratio 1.5) in one patient and true-negative in seven while the other' imaging modalities had four false-positives. The average201T1 ratios were 3.8±1.1 in the true-positive cases and 1.3±0.3 in the true-negative cases. The percentage sensitivities, specificities, and accuracy for201T1 were 100%, 87.5%, and 96.5% versus 95%, 50%, and 82.7% respectively for other imaging modalities These results indicate that201T1 scintigraphy is more accurate than other imaging modalities in differentiating residual/recurrent musculoskeletal sarcomas from post-therapy changes. © 1995 Springer-Verlag.
Keywords:	osteosarcoma; adolescent; adult; child; clinical article; school child; aged; aged, 80 and over; bone neoplasms; clinical trial; histopathology; comparative study; nuclear magnetic resonance imaging; magnetic resonance imaging; diagnostic accuracy; prospective study; sensitivity and specificity; prospective studies; computer assisted tomography; neoplasm recurrence, local; tomography, x-ray computed; tumor biopsy; sarcoma; neoplasm, residual; radiopharmaceutical agent; soft tissue sarcoma; muscle neoplasms; cancer scintiscanning; angiography; intravenous drug administration; thallium radioisotopes; tomography, emission-computed, single-photon; middle age; thallium-201; thallium; thallium chloride tl 201; human; male; female; article; post-therapy changes; residual/recurrent tumors; soft tissue sarcomas
Journal Title:	European Journal of Nuclear Medicine
Volume:	22
Issue:	11
ISSN:	0340-6997
Publisher:	Springer Verlag
Date Published:	1995-11-01
Start Page:	1232
End Page:	1237
Language:	English
DOI:	10.1007/bf00801605
PUBMED:	8575469
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028811511&doi=10.1007%2fBF00801605&partnerID=40&md5=40d35d4f848c2cd1d1ed33d378cc362c
Notes:	Article -- Export Date: 28 August 2018 -- Source: Scopus

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