TGFβ signals through a heteromeric protein kinase receptor complex Journal Article
| Authors: | Wrana, J. L.; Attisano, L.; Cárcamo, J.; Zentella, A.; Doody, J.; Laiho, M.; Wang, X. F.; Massagué, J. |
| Article Title: | TGFβ signals through a heteromeric protein kinase receptor complex |
| Abstract: | Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors. © 1992. |
| Keywords: | signal transduction; nonhuman; polymerase chain reaction; animal cell; animal; models, biological; protein kinases; serine; transforming growth factor beta; cell line; luciferase; protein binding; enzyme activity; animalia; amino acid sequence; molecular sequence data; nucleotide sequence; membrane protein; threonine; receptor affinity; protein structure; multienzyme complexes; protein kinase; complementary dna; polyacrylamide gel electrophoresis; mink; receptors, cell surface; binding, competitive; growth factor receptor; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Cell |
| Volume: | 71 |
| Issue: | 6 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 1992-12-11 |
| Start Page: | 1003 |
| End Page: | 1014 |
| Language: | English |
| DOI: | 10.1016/0092-8674(92)90395-s |
| PUBMED: | 1333888 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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