Very CIN-ful: Whole Chromosome Instability Promotes Tumor Suppressor Loss of Heterozygosity Journal Article
| Authors: | Sotillo, R.; Schvartzman, J. M.; Benezra, R. |
| Article Title: | Very CIN-ful: Whole Chromosome Instability Promotes Tumor Suppressor Loss of Heterozygosity |
| Abstract: | Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | cancer growth; nonhuman; mitosis; gene overexpression; protein p53; cancer model; carcinogenesis; tumor suppressor gene; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; gene duplication; short survey; chromosomal instability; heterozygosity loss; loss of heterozygosity; loss of function mutation; aneuploidy; apc protein; genes, tumor suppressor; chromosome segregation; mitotic checkpoint |
| Journal Title: | Cancer Cell |
| Volume: | 16 |
| Issue: | 6 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2009-12-08 |
| Start Page: | 451 |
| End Page: | 452 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2009.11.014 |
| PUBMED: | 19962661 |
| PROVIDER: | scopus |
| PMCID: | PMC5513159 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: CCAEC" - "Source: Scopus" |
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