A context dependent role for Wnt signaling in tumorigenesis and stem cells Journal Article
| Authors: | Matushansky, I.; Maki, R. G.; Cardo, C. C. |
| Article Title: | A context dependent role for Wnt signaling in tumorigenesis and stem cells |
| Abstract: | The Wnt signal transduction pathway coordinates myriad activities, from development and differentiation to proliferation and tumorigenesis. What is perhaps most remarkable is that Wnt signaling is able to accomplish this diverse set of activities in a cell-specific and differentiation stage-dependent manner. In this review, we will highlight the diverse effect of Wnt signaling on three types of tissue stem cells and their corresponding malignancies. ©2008 Landes Bioscience. |
| Keywords: | signal transduction; leukemia; review; nonhuman; protein function; colorectal cancer; cell proliferation; cell differentiation; carcinogenesis; stem cell; sarcoma; colorectal neoplasms; epithelium cell; epithelial cells; stem cells; mesenchymal stem cell; hematopoietic stem cell; wnt proteins; wnt protein; sarcomas; differentiation; wnt; β-catenin |
| Journal Title: | Cell Cycle |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2008-03-15 |
| Start Page: | 720 |
| End Page: | 724 |
| Language: | English |
| PUBMED: | 18239459 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "Source: Scopus" |
