Newer approaches in treating chronic myelogenous leukemia Conference Paper

  


Authors: Gulati, S. C.; Lemoli, R.; Van Poznak, C.
Title: Newer approaches in treating chronic myelogenous leukemia
Conference Title: 2nd International Conference on Chronic Myeloid Leukemia
Abstract: We evaluated the recovery of human hematopoietic progenitors in long-term bone marrow culture (LTBMC) initiated in tissue culture (TC) flasks to that in ''Lifecell'' bags, which are gas-permeable plastic bags in which feeder-layer cells cannot adhere. Cells were incubated in presence of IL-1 and IL-3. Our experiments reveal sustained hematopoietic stem cell growth in the absence of a feeder layer in plastic gas-permeable bags. Evaluations of marrow from patients with chronic myelogenous leukemia suggests enrichment of normal hematopoietic precursors. Combining effective drugs to decrease Ph(+) clone prior to bone marrow harvest and use of cultured bone marrow may provide a useful method for treating patients with chronic myelogenous leukemia.
Keywords: cml; bm culture; ltbmc
Journal Title Leukemia and Lymphoma
Volume: 11
Issue: Suppl. 1
Conference Dates: 1992 Oct 4-7
Conference Location: Bologna, Italy
ISBN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 1993-01-01
Start Page: 293
End Page: 296
Language: English
ACCESSION: WOS:A1993MA14500049
DOI: 10.3109/10428199309047901
PROVIDER: wos
PUBMED: 8251910
Notes: Article -- Source: Wos
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MSK Authors
  1. Catherine H Van Poznak
    52 Van Poznak
  2. Subhash C. Gulati
    129 Gulati
  3. Roberto M. Lemoli
    18 Lemoli
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