Newer approaches in treating chronic myelogenous leukemia Conference Paper
| Authors: | Gulati, S.; Lemoli, R.; Fraig, M. |
| Title: | Newer approaches in treating chronic myelogenous leukemia |
| Conference Title: | Portofino Symposium - Autografting for Chronic Myeloid Leukemia: Status of the Art |
| Abstract: | Allogeneic bone marrow transplantation (BMT) is a useful approach for treating patients with chronic myelogenous leukemia (CML). In patients who lack a suitable donor, various approaches to utilize the patient's own hematopoietic stem cells obtained from bone marrow and/or peripheral blood have been developed. Preferential recovery of normal human hematopoietic progenitors over CML clone in long‐term bone marrow culture (LTBMC) has been observed for a long time. LTBMC initiated in tissue culture (TC) flasks to that in “Lifecell” bags, which are gas‐permeable plastic bags in which feeder‐layer cells cannot adhere, has been investigated for several years. In our laboratory, cells were incubated in the presence of various growth factors to develop improved methods for stem cell expansion. Sustained hematopoietic stem cell growth in the absence of a feeder layer in plastic gas‐permeable bags has been observed. Growth of marrow from patients with CML is being investigated extensively. Combining effective drugs to decrease the Philadelphia (Ph) clone prior to bone marrow harvest and the use of cultured bone marrow may provide a useful method for treating patients with CML. Results of various international studies are also discussed below. Copyright © 1993 AlphaMed Press |
| Keywords: | controlled study; human cell; comparative study; cytarabine; cells, cultured; granulocyte macrophage colony stimulating factor; allogenic bone marrow transplantation; hematopoietic stem cell transplantation; cml; chronic myeloid leukemia; hematopoietic stem cell; blood cell count; bone marrow transplantation; stromal cells; granulocyte colony stimulating factor; colony forming unit gm; philadelphia 1 chromosome; tissue culture; recombinant interleukin 3; erythroid progenitor cells; bone marrow purging; burst forming unit e; leukemia, myeloid, chronic; human; article; support, non-u.s. gov't; recombinant interleukin 1; bone marrow culture; bm culture; ltbmc |
| Journal Title | Stem Cells |
| Volume: | 11 |
| Issue: | Suppl. 3 |
| Conference Dates: | 1993 Aug 19-20 |
| Conference Location: | Portofino (Genoa), Italy |
| ISBN: | 1066-5099 |
| Publisher: | AlphaMed Press |
| Date Published: | 1993-10-01 |
| Start Page: | 14 |
| End Page: | 19 |
| Language: | English |
| DOI: | 10.1002/stem.5530110906 |
| PUBMED: | 7905321 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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