Can exercise-induced modulation of the tumor physiologic microenvironment improve antitumor immunity? Journal Article


Authors: Zhang, X.; Ashcraft, K. A.; Warner, A. B.; Nair, S. K.; Dewhirst, M. W.
Article Title: Can exercise-induced modulation of the tumor physiologic microenvironment improve antitumor immunity?
Abstract: The immune system plays an important role in controlling cancer growth. However, cancers evolve to evade immune detection. Immune tolerance and active immune suppression results in unchecked cancer growth and progression. A major contributor to immune tolerance is the tumor physiologic microenvironment, which includes hypoxia, hypoglucosis, lactosis, and reduced pH. Preclinical and human studies suggest that exercise elicits mobilization of leukocytes into circulation (also known as "exercise-induced leukocytosis"), especially cytotoxic T cells and natural killer cells. However, the tumor physiologic microenvironment presents a significant barrier for these cells to enter the tumor and, once there, properly function. We hypothesize that the effect of exercise on the immune system's ability to control cancer growth is linked to how exercise affects the tumor physiologic microenvironment. Normalization of the microenvironment by exercise may promote more efficient innate and adaptive immunity within the tumor. This review summarizes the current literature supporting this hypothesis. © 2019 American Association for Cancer Research.
Journal Title: Cancer Research
Volume: 79
Issue: 10
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 2019-05-15
Start Page: 2447
End Page: 2456
Language: English
DOI: 10.1158/0008-5472.Can-18-2468
PUBMED: 31068341
PROVIDER: scopus
DOI/URL:
Notes: Review -- Source: Scopus
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MSK Authors
  1. Allison Betof Warner
    13 Warner