Exercise-dependent regulation of the tumour microenvironment Journal Article
| Authors: | Koelwyn, G. J.; Quail, D. F.; Zhang, X.; White, R. M.; Jones, L. W. |
| Article Title: | Exercise-dependent regulation of the tumour microenvironment |
| Abstract: | The integrity and composition of the tumour microenvironment (TME) is highly plastic, undergoing constant remodelling in response to instructive signals derived from alterations in the availability and nature of systemic host factors. This 'systemic milieu' is directly modulated by host exposure to modifiable lifestyle factors such as exercise. Host exposure to regular exercise markedly reduces the risk of the primary development of several cancers and might improve clinical outcomes following a diagnosis of a primary disease. However, the molecular mechanisms that underpin the apparent antitumour effects of exercise are poorly understood. In this Opinion article, we explore the putative effects of exercise in reprogramming the interaction between the host and the TME. Specifically, we speculate on the possible effects of exercise on reprogramming 'distant' tissue microenvironments (those not directly involved in the exercise response) by analysing how alterations in the systemic milieu might modulate key TME components to influence cancer hallmarks. © 2017 Macmillan Publishers Limited, part of Springer Nature. |
| Keywords: | pathophysiology; neoplasms; mouse; animal; metabolism; animals; mice; animal experiment; exercise; angiogenesis; neovascularization, pathologic; vascularization; physiology; immunology; innate immunity; immunity, innate; autophagy; adaptive immunity; neovascularization, physiologic; neovascularization (pathology); skeletal muscle; kinesiotherapy; muscle, skeletal; tumor microenvironment; exercise therapy; adaptation; physical conditioning, animal; humans; human; adaptation, physiological |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 17 |
| Issue: | 10 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2017-10-01 |
| Start Page: | 620 |
| End Page: | 632 |
| Language: | English |
| DOI: | 10.1038/nrc.2017.78 |
| PUBMED: | 28943640 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 November 2017 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work