Overview of thrombopoietic agents in the treatment of thrombocytopenia Journal Article
| Authors: | Kobos, R.; Bussel, J. B. |
| Article Title: | Overview of thrombopoietic agents in the treatment of thrombocytopenia |
| Abstract: | Pharmaceutical advances in the field of hematology have led to promising new options for the management of thrombocytopenia. This overview provides both a brief review of historical management of thrombocytopenia and a more detailed look at the novel thrombopoietic agents currently being investigated for their utility in treating thrombocytopenia. Specific agents that enhance thrombopoiesis will alter the overall approach to immune thrombocytopenia purpura. Development of these agents might also improve the management of diseases such as cancer and hepatitis C, whose current regimens are limited by the occurrence of thrombocytopenia. |
| Keywords: | unclassified drug; clinical trial; fatigue; review; doxorubicin; fluorouracil; interferon; advanced cancer; drug efficacy; drug safety; drug withdrawal; hepatitis c; nonhuman; solid tumor; paclitaxel; cytarabine; neoplasm; animals; carboplatin; multiple cycle treatment; etoposide; thrombocytopenia; lung cancer; cyclophosphamide; dyspnea; sarcoma; thorax pain; pyrazoles; carrier proteins; recombinant proteins; mitoxantrone; daunorubicin; acute myeloblastic leukemia; peripheral edema; headache; hematopoietic stem cell; idarubicin; drug dose increase; epistaxis; heart atrium fibrillation; megakaryocyte; female genital tract tumor; hemorrhoid; megakaryocytes; hydrazines; thrombopoietin; akr 501; eltrombopag; neutralizing antibody; myositis; thrombopoiesis; bloody diarrhea; thrombocytopoiesis; gingiva bleeding; akr-501; amg-531; interleukin-11; dimethoate; interleukin 11; lgd 4665; nip 004; recombinant megakaryocyte growth and development factor; recombinant thrombopoietin; remiplistim; sb 559448; conjunctival hemorrhage; contusion; menorrhagia; thrombocytopenic purpura; benzoic acids; purpura, thrombocytopenic, idiopathic; receptors, fc |
| Journal Title: | Clinical Lymphoma and Myeloma |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 1557-9190 |
| Publisher: | Cancer Information Group |
| Date Published: | 2008-02-01 |
| Start Page: | 33 |
| End Page: | 43 |
| Language: | English |
| DOI: | 10.3816/CLM.2008.n.002 |
| PUBMED: | 18501086 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "Source: Scopus" |
