Myelodysplastic syndromes: Clinical Practice Guidelines in Oncology Journal Article

  


Authors: Greenberg, P. L.; Baer, M. R.; Bennett, J. M.; Bloomfield, C. D.; De Castro, C. M.; Deeg, H. J.; Devetten, M. P.; Emanuel, P. D.; Erba, H. P.; Estey, E.; Foran, J.; Gore, S. D.; Millenson, M.; Navarro, W. H.; Nimer, S. D.; O'Donnell, M. R.; Saba, H. I.; Spiers, K.; Stone, R. M.; Tallman, M. S.
Article Title: Myelodysplastic syndromes: Clinical Practice Guidelines in Oncology
Abstract: These suggested practice guidelines are based on extensive evaluation of the reviewed risk-based data and indicate useful current approaches for managing patients with MDS. Given the limited number of studies comparing different therapies in MDS, most of the therapeutic drugs used to treat this disease should be assessed in the context of clinical trials. Several clinical trials are ongoing to assess the efficacy of novel biospecific agents in this disease. The role of thrombopoietic cytokines for management of thrombocytopenia in MDS needs further evaluation. In addition, further determination of the effects of these therapeutic interventions on the patient's quality of life is important. Progress toward improving management of MDS has occurred over the past few years, and more such advances are anticipated using these guidelines as a framework for coordination of comparative clinical trials. © Journal of the National Comprehensive Cancer Network.
Keywords: antibiotic agent; acute granulocytic leukemia; chronic myelomonocytic leukemia; lenalidomide; thalidomide; clinical trial; neutropenia; review; disease classification; treatment; anemia; bleeding; thrombocytopenia; nccn clinical practice guidelines; patient assessment; hematopoietic stem cell transplantation; chronic myeloid leukemia; myelodysplastic syndrome; hybrid protein; laboratory test; iron; blood transfusion; allogeneic hematopoietic stem cell transplantation; 5 aza 2' deoxycytidine; tumor necrosis factor receptor; folic acid; high risk population; cyclosporin a; drug dose regimen; bacterial infection; granulocyte colony stimulating factor; cytopenia; recombinant erythropoietin; deferoxamine; azacitidine; myelodysplastic syndromes; thymocyte antibody; cyanocobalamin; cytopenias; refractory anemia; deferasirox; novel erythropoiesis stimulating protein; iron overload; aminocaproic acid; deferiprone; antifibrinolytic agent; iron chelating agent; vitamin d derivative
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 4
Issue: 1
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2006-01-01
Start Page: 58
End Page: 77
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33645057481&partnerID=40&md5=579730d166fa41446ca5574fea531039
Notes: --- - "Cited By (since 1996): 34" - "Export Date: 4 June 2012" - "Source: Scopus"