Venetoclax: Management and care for patients with relapsed or refractory chronic lymphocytic leukemia Journal Article


Authors: Paradis, H. B.; Alter, D.; Llerandi, D.
Article Title: Venetoclax: Management and care for patients with relapsed or refractory chronic lymphocytic leukemia
Abstract: BACKGROUND: Venetoclax (Venclexta™) is a potent, selective, orally available, small-molecule B-cell lymphoma 2 inhibitor that achieves response rates of about 80% and has an acceptable safety profile for patients with relapsed or refractory chronic lymphocytic leukemia (CLL). OBJECTIVES: The aim was to describe treatment management considerations when caring for patients using venetoclax. METHODS: A review was done of safety and management considerations based on current clinical practice and 240 patients with CLL who received venetoclax monotherapy on clinical trials from 2011–2016. FINDINGS: Common adverse events were neutro-penia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue. Because of rapid tumor reduction with venetoclax, nurses should be aware of the potential for tumor lysis syndrome (TLS) and the need to educate patients on steps to minimize risks, including gradual dose ramp-up, adequate hydration, and use of prophylactic antihyperuricemia agents. Following implementation of these risk-reducing measures, no clinical TLS events were reported in ongoing trials. © 2017, Oncology Nursing Society. All rights reserved.
Keywords: safety; dosing; chronic lymphocytic leukemia; venetoclax; bcl-2 inhibitor
Journal Title: Clinical Journal of Oncology Nursing
Volume: 21
Issue: 5
ISSN: 1092-1095
Publisher: Oncology Nursing Society (ONS)  
Date Published: 2017-10-01
Start Page: 604
End Page: 610
Language: English
DOI: 10.1188/17.cjon.604-610
PROVIDER: scopus
PUBMED: 28945711
DOI/URL:
Notes: Article -- Export Date: 2 November 2017 -- Source: Scopus
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