Gastrointestinal stromal tumors and leiomyosarcomas Journal Article
| Authors: | Katz, S. C.; DeMatteo, R. P. |
| Article Title: | Gastrointestinal stromal tumors and leiomyosarcomas |
| Abstract: | Only recently has gastrointestinal stromal tumor (GIST) been recognized as the most frequent GI mesenchymal neoplasm. Prior to the use of KIT staining, most GI stromal tumors were identified as leiomyosarcoma (LMS). For primary GIST, surgery remains the principal treatment and adjuvant imatinib may improve outcomes. Multimodality therapy may also be effective in patients with metastatic GIST. In this review, we summarize the epidemiology, clinicopathologic features, natural history, and clinical management of LMS and GIST. © 2008 Wiley-Liss, Inc. |
| Keywords: | cancer chemotherapy; treatment outcome; cancer surgery; gene mutation; clinical feature; clinical trial; review; placebo; drug dose comparison; multimodality cancer therapy; unspecified side effect; adjuvant therapy; combined modality therapy; nuclear magnetic resonance imaging; positron emission tomography; laparotomy; cell proliferation; gastrointestinal stromal tumor; imatinib; tumor localization; gastrointestinal stromal tumors; metastasis; computer assisted tomography; tumor volume; algorithms; cancer therapy; histology; sarcoma; cancer invasion; drug response; staining; fluorodeoxyglucose f 18; mitosis rate; leiomyosarcoma; gist; drug binding |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 97 |
| Issue: | 4 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-03-15 |
| Start Page: | 350 |
| End Page: | 359 |
| Language: | English |
| DOI: | 10.1002/jso.20970 |
| PUBMED: | 18286477 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 31" - "Export Date: 17 November 2011" - "CODEN: JSONA" - "Source: Scopus" |
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