Case report: Clinical and molecular features of renal gastrointestinal tumor Journal Article
| Authors: | Makker, S.; Rammal, R.; Gu, P.; Dalbagni, G.; Al-Ahmadie, H.; Agaram, N. P.; Iyer, G.; Kotecha, R. R. |
| Article Title: | Case report: Clinical and molecular features of renal gastrointestinal tumor |
| Abstract: | While gastrointestinal stromal tumors (GISTs) often arise within the GI tract, it is well known that GISTs may also rarely emanate outside of the digestive system. Prior case reports have documented various primary sites in non-GI organs [extra-intestinal GIST (EGIST)], yet only one report has described a localized GIST of renal origin. Here, we describe a patient who presented with bilateral renal masses who was found to have a large unresectable renal GIST tumor treated with imatinib. We discuss treatment experience and response with systemic therapy and describe molecular data to contextualize this ultra-rare presentation within the landscape of EGIST tumors. Copyright © 2025 Makker, Rammal, Gu, Dalbagni, Al-Ahmadie, Agaram, Iyer and Kotecha. |
| Keywords: | immunohistochemistry; adult; clinical article; human tissue; aged; histopathology; case report; systemic therapy; follow up; gastrointestinal stromal tumor; imatinib; computer assisted tomography; anemia; hemoglobin; creatinine blood level; protein p53; abdominal pain; kidney tumor; renal mass; fluorodeoxyglucose f 18; tumor cell; protein s 100; prostate hypertrophy; kit; gene dosage; gist; fluorodeoxyglucose; cyclin dependent kinase 4; abdominal distension; gastrointestinal tumor; maximum standardized uptake value; high throughput sequencing; human; male; article; positron emission tomography-computed tomography; mouse double minute 2 homolog; desmin (protein) |
| Journal Title: | Frontiers in Oncology |
| Volume: | 15 |
| ISSN: | 2234-943X |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2025-02-13 |
| Start Page: | 1508600 |
| Language: | English |
| DOI: | 10.3389/fonc.2025.1508600 |
| PROVIDER: | scopus |
| PMCID: | PMC11865245 |
| PUBMED: | 40018405 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Ritesh Kotecha -- Source: Scopus |
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