The association of renal cell carcinoma with gastrointestinal stromal tumors Journal Article

Authors: Mendonca, S. J.; Sanchez, A.; Blum, K. A.; Ghanaat, M.; Kashan, M. Y.; Benfante, N.; Russo, P.; Coleman, J. A.; Crago, A. M.; Hakimi, A. A.
Article Title: The association of renal cell carcinoma with gastrointestinal stromal tumors
Abstract: Background and Objectives: Prior small studies have reported a possible association between renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). In the largest known series, our objective was to describe the prevalence of RCC among patients with GISTs over 26 years at Memorial Sloan Kettering Cancer Center (MSKCC). Methods: We retrospectively reviewed MSKCC's prospectively maintained sarcoma and RCC databases and identified all patients with both RCC and GIST between 1980 and 2016. Demographic and clinicopathological characteristics were obtained. Results: A total of 9/405 (2.2%) GIST patients were identified with RCC, with a mean follow-up of 9.2 (range 3.8-28.4) years. Five out of nine (55.6%) patients had RCC and GIST diagnosis within 6 months of each other. Mean RCC tumor size was 3.0 (range 1.8-8) cm and 8/9 (88.9%) patients were RCC stage 1. A total of 4/9 (44.4%) patients had papillary RCC (pRCC) histology, 5/9 (55.6%) had additional alternative malignancies, and 4/9 (44.4%) had primary small bowel GIST. Conclusions: Our series suggests a possible association of RCC with GISTs. In addition, we found a high frequency of pRCC histology, alternative malignancies, and small bowel GISTs in co-occurring RCC-GIST patients. Further investigation to identify genetic mutations, in this population, would assist in surveillance and treatment. © 2018 Wiley Periodicals, Inc.
Keywords: adult; clinical article; aged; middle aged; cancer surgery; retrospective studies; cancer patient; cancer staging; follow up; gastrointestinal stromal tumor; gastrointestinal stromal tumors; prevalence; pathology; medical record review; retrospective study; renal cell carcinoma; kidney neoplasms; gastrointestinal neoplasms; partial nephrectomy; radical nephrectomy; kidney tumor; carcinoma, renal cell; cancer size; neoplasms, second primary; second cancer; epidemiology; new york; gastrointestinal tumor; humans; human; male; female; priority journal; article; clinical association
Journal Title: Journal of Surgical Oncology
Volume: 117
Issue: 8
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2018-06-15
Start Page: 1716
End Page: 1720
Language: English
DOI: 10.1002/jso.25080
PUBMED: 29878354
PROVIDER: scopus
PMCID: PMC6135662
Notes: Article -- Export Date: 1 October 2018 -- Source: Scopus
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MSK Authors
  1. Jonathan Coleman
    192 Coleman
  2. Paul Russo
    459 Russo
  3. Aimee Marie Crago
    57 Crago
  4. Abraham Ari Hakimi
    134 Hakimi
  5. Mahyar   Kashan
    7 Kashan
  6. Mazyar   Ghanaat
    10 Ghanaat
  7. Kyle Blum
    7 Blum