A high spatial resolution 1H magnetic resonance spectroscopic imaging technique for breast cancer with a short echo time Journal Article
| Authors: | Hu, J.; Yu, Y.; Kou, Z.; Huang, W.; Jiang, Q.; Xuan, Y.; Li, T.; Sehgal, V.; Blake, C.; Haacke, E. M.; Soulen, R. L. |
| Article Title: | A high spatial resolution 1H magnetic resonance spectroscopic imaging technique for breast cancer with a short echo time |
| Abstract: | The high sensitivity but low specificity of breast MRI has prompted exploration of breast 1H MRS for breast cancer detection. However, several obstacles still prevent the routine application of in vivo breast 1H MRS, including poor spatial resolution, long acquisition time associated with conventional multi-voxel MRS imaging (MRSI) techniques, and the difficulty of "extra" lipid suppression in a magnetic field with relatively poor achievable homogeneity compared to the brain. Using a combination of a recently developed echo-filter (EF) suppression technique and an elliptical sampling scheme, we demonstrate the feasibility of overcoming these difficulties. It is robust (the suppression technique is insensitive to magnetic field inhomogeneity), fast (acquisition time of about 12 min) and offers high spatial resolution (up to 0.6 cm3 per voxel at 1.5 T with a TE of only 60 ms). This approach should be even better at 3 T with higher resolution and/or shorter TE. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | adult; clinical article; controlled study; aged; aged, 80 and over; middle aged; cancer diagnosis; sensitivity and specificity; breast cancer; in vivo study; breast neoplasms; feasibility studies; magnetic resonance spectroscopy; choline; contrast media; fibroadenoma; spectroscopy; proton nuclear magnetic resonance; magnetic field; echo-filter; high spatial resolution; short te |
| Journal Title: | Magnetic Resonance Imaging |
| Volume: | 26 |
| Issue: | 3 |
| ISSN: | 0730-725X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2008-04-01 |
| Start Page: | 360 |
| End Page: | 366 |
| Language: | English |
| DOI: | 10.1016/j.mri.2007.07.004 |
| PUBMED: | 17904326 |
| PROVIDER: | scopus |
| PMCID: | PMC3805364 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: MRIMD" - "Source: Scopus" |
