Proton MR spectroscopy in the breast: Technical innovations and clinical applications Review

   


Authors: Fardanesh, R.; Marino, M. A.; Avendano, D.; Leithner, D.; Pinker, K.; Thakur, S. B.
Review Title: Proton MR spectroscopy in the breast: Technical innovations and clinical applications
Abstract: Proton magnetic resonance spectroscopy (MRS) is a promising noninvasive diagnostic technique for investigation of breast cancer metabolism. Spectroscopic imaging data may be obtained following contrast-enhanced MRI by applying the point-resolved spectroscopy sequence (PRESS) or the stimulated echo acquisition mode (STEAM) sequence from the MR voxel encompassing the breast lesion. Total choline signal (tCho) measured in vivo using either a qualitative or quantitative approach has been used as a diagnostic test in the workup of malignant breast lesions. In addition to tCho metabolites, other relevant metabolites, including multiple lipids, can be detected and monitored. MRS has been heavily investigated as an adjunct to morphologic and dynamic MRI to improve diagnostic accuracy in breast cancer, obviating unnecessary benign biopsies. Besides its use in the staging of breast cancer, other promising applications have been recently investigated, including the assessment of treatment response and therapy monitoring. This review provides guidance on spectroscopic acquisition and quantification methods and highlights current and evolving clinical applications of proton MRS. Level of Evidence 5. Technical Efficacy: Stage 5. J. Magn. Reson. Imaging 2019. © 2019 International Society for Magnetic Resonance in Medicine
Keywords: contrast-enhanced mri; proton mr spectroscopy; breast cancer metabolism; choline metabolites; lipid metabolites
Journal Title: Journal of Magnetic Resonance Imaging
Volume: 50
Issue: 4
ISSN: 1053-1807
Publisher: Wiley Blackwell  
Date Published: 2019-10-01
Start Page: 1033
End Page: 1046
Language: English
DOI: 10.1002/jmri.26700
PUBMED: 30848037
PROVIDER: scopus
PMCID: PMC6732054
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062794216&doi=10.1002%2fjmri.26700&partnerID=40&md5=a1811a71db7b730bc7665d0e730f8dc5
Notes: Review -- Export Date: 1 November 2019 -- Source: Scopus
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MSK Authors
  1. Sunitha Bai Thakur
    100 Thakur
  2. Katja Pinker-Domenig
    213 Pinker-Domenig
  3. Doris Leithner
    43 Leithner
  4. Daly Betzabeth Avendano
    14 Avendano
  5. Maria Adele Marino
    16 Marino
  6. Reza Fardanesh
    3 Fardanesh
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