Modeling cancer in the CRISPR era Journal Article
| Authors: | Ventura, A.; Dow, L. E. |
| Article Title: | Modeling cancer in the CRISPR era |
| Abstract: | In just a few short years, CRISPR/Cas9 genome editing has fundamentally changed basic, agricultural, and biomedical research, but no field has felt a more profound impact than cancer research. The ability to quickly and precisely manipulate the genome has opened the floodgates for a new and more elaborate understanding of how genes and gene regulation influence disease. Here we review how the development and implementation of CRISPR-based technology is redefining the way we study cancer, and ultimately how it may be used to improve treatment outcomes. |
| Keywords: | in-vivo; genome; endonuclease; in vivo; colorectal-cancer; mouse model; human-cells; cancer; cas9; crispr; genome editing; one-step generation; oncogenic chromosomal rearrangements; rna-guided; cynomolgus monkey; dystrophin gene |
| Journal Title: | Annual Review of Cancer Biology |
| Volume: | 2 |
| ISSN: | 2472-3428 |
| Publisher: | Annual Reviews |
| Date Published: | 2018-01-01 |
| Start Page: | 111 |
| End Page: | 131 |
| Language: | English |
| ACCESSION: | WOS:000462706100007 |
| PROVIDER: | wos |
| DOI: | 10.1146/annurev-cancerbio-030617-050455 |
| Notes: | Source: Wos |
