Novel therapies and role of transplant in the treatment of peripheral T-cell lymphomas Journal Article


Author: Horwitz, S. M.
Article Title: Novel therapies and role of transplant in the treatment of peripheral T-cell lymphomas
Abstract: Peripheral T-cell lymphomas (PTCL) are an uncommon, heterogeneous group of non-Hodgkin lymphomas that carry a much poorer prognosis than their more common B-cell counterparts. The most commonly used treatment is CHOP or its variations. However, while the results with CHOP are inadequate, there is little compelling data to suggest a preferred alternate strategy. Many of these alternate strategies have been assembled from retrospective data, small case series, subset analyses, phase II studies and individual experience. The greatest experience with alternative treatments has been with the use of high-dose therapy as consolidation. These approaches are promising, but most of the studies are retrospective and include patients with diverse prognoses, making interpretation difficult. Preliminary results of prospective trials in PTCL are only recently being reported. Perhaps more exciting have been the increasing numbers of new therapies being studied for patients with PTCL. The activities of new drugs are being described in studies specifically for PTCL, and attempts at novel combinations are beginning.
Keywords: survival rate; retrospective studies; prednisone; mortality; doxorubicin; methodology; antineoplastic agent; antineoplastic combined chemotherapy protocols; cyclophosphamide; dexamethasone; vincristine; stem cell transplantation; retrospective study; peripheral t cell lymphoma; transplantation, autologous; depsipeptides; depsipeptide; lymphoma, t-cell, peripheral; autotransplantation; chop protocol; cvad protocol
Journal Title: Hematology-American Society of Hematology Education Program
ISSN: 1520-4391
Publisher: American Society of Hematology  
Date Published: 2008-01-01
Start Page: 289
End Page: 296
Language: English
PUBMED: 19074098
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "Source: Scopus"