Entosis controls a developmental cell clearance in C. elegans Journal Article


Authors: Lee, Y.; Hamann, J. C.; Pellegrino, M.; Durgan, J.; Domart, M. C.; Collinson, L. M.; Haynes, C. M.; Florey, O.; Overholtzer, M.
Article Title: Entosis controls a developmental cell clearance in C. elegans
Abstract: Entosis is a cell death mechanism, previously observed in cancer cell populations, that involves the invasion of live cells into their neighbors. Lee et al. now show that entosis has a developmental function in C. elegans, clearing the linker cell during gonad formation. © 2019 The Authors Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to clear the male-specific linker cell in C. elegans. The linker cell leads migration to shape the gonad and is removed to facilitate fusion of the gonad to the cloaca. We find that the linker cell is cleared in a manner involving cell-cell adhesions and cell-autonomous control of uptake through linker cell actin. Linker cell entosis generates a lobe structure that is deposited at the site of gonad-to-cloaca fusion and is removed during mating. Inhibition of lobe scission inhibits linker cell death, demonstrating that the linker cell invades its host while alive. Our findings demonstrate a developmental function for entosis: to eliminate a migrating cell and facilitate gonad-to-cloaca fusion, which is required for fertility. © 2019 The Authors
Keywords: controlled study; nonhuman; cell death; cell population; cancer cell; caenorhabditis elegans; cell adhesion; gonad; entosis; cannibalism; clearance; entotic cell death; lobe; cell cannibalism; engulfment; human; article; linker cell death; scission; uropod
Journal Title: Cell Reports
Volume: 26
Issue: 12
ISSN: 2211-1247
Publisher: Cell Press  
Date Published: 2019-03-19
Start Page: 3212
End Page: 3220.e4
Language: English
DOI: 10.1016/j.celrep.2019.02.073
PROVIDER: scopus
PUBMED: 30893595
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Jens C Hamann
    8 Hamann
  2. Yongchan Lee
    3 Lee