A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition Journal Article
| Authors: | Mathias, M. D.; Ortiz, M. V.; Magnan, H.; Ambati, S. R.; Slotkin, E. K.; Chou, A. J.; Walsh, M. F.; Offit, K.; Moskowitz, C.; Kentsis, A.; Wexler, L. H. |
| Article Title: | A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition |
| Abstract: | Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. Case presentation: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. Conclusions: This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen. © The Author(s). 2017. |
| Keywords: | adult; cancer chemotherapy; human tissue; antibiotic agent; gene sequence; somatic mutation; prednisone; constipation; neutropenia; case report; doxorubicin; rituximab; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; allele; cancer susceptibility; mucosa inflammation; cyclophosphamide; vincristine; bone pain; molecular analysis; dactinomycin; glucocorticoid; neurofibromin; large cell lymphoma; rhabdomyosarcoma; granulocyte colony stimulating factor; embryonal rhabdomyosarcoma; personalized medicine; fine needle aspiration biopsy; diffuse large b cell lymphoma; cancer prognosis; human; female; priority journal; article |
| Journal Title: | Biomarker Research |
| Volume: | 5 |
| ISSN: | 2050-7771 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2017-02-08 |
| Start Page: | 7 |
| Language: | English |
| DOI: | 10.1186/s40364-017-0086-7 |
| PROVIDER: | scopus |
| PMCID: | PMC5299656 |
| PUBMED: | 28194276 |
| DOI/URL: | |
| Notes: | Source: Scopus |
