FDG-avid intrathecal inflammation following administration of intrathecal methotrexate Journal Article
| Authors: | Hogan, M. P.; Osborne, J.; Ulaner, G. A. |
| Article Title: | FDG-avid intrathecal inflammation following administration of intrathecal methotrexate |
| Abstract: | Intrathecal methotrexate is a standard option for central nervous system-directed therapy in patients with stage III and IV diffuse large B-cell lymphoma. We present a case of a 50-year-old man with stage IV diffuse large B-cell lymphoma with widespread lymphomatous involvement including the central nervous system, who received 7 doses of intrathecal methotrexate via Ommaya catheter. Posttherapy F-FDG-PET/CT imaging demonstrated diffuse, intense intrathecal FDG avidity, without correlative findings on MR spinal imaging. FDG avidity resolved on follow-up. These PET/CT findings are most consistent with methotrexate-induced thecal inflammation, which needs to be distinguished from intrathecal malignancy. |
| Keywords: | middle aged; case report; methotrexate; antimetabolites, antineoplastic; inflammation; diagnostic imaging; lymphoma, large b-cell, diffuse; antineoplastic antimetabolite; spine disease; procedures; humans; human; male; spinal diseases; positron emission tomography-computed tomography; positron emission tomography computed tomography |
| Journal Title: | Clinical Nuclear Medicine |
| Volume: | 41 |
| Issue: | 12 |
| ISSN: | 0363-9762 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2016-12-01 |
| Start Page: | 995 |
| End Page: | 997 |
| Language: | English |
| PUBMED: | 27805919 |
| PROVIDER: | scopus |
| DOI: | 10.1097/rlu.0000000000001440 |
| PMCID: | PMC5583704 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2017 -- Source: Scopus |
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