Characterization of T-cell lymphomas by FDG PET/CT Journal Article

Authors: Feeney, J.; Horwitz, S.; Gonen, M.; Schoder, H.
Article Title: Characterization of T-cell lymphomas by FDG PET/CT
Abstract: OBJECTIVE. The purpose of this article is to describe the utility of FDG PET/CT in documenting sites of disease in patients with T-cell lymphomas, to quantify the degree of FDG avidity in the various subtypes of this heterogeneous group of disorders, and to highlight the pattern of imaging findings associated with specific disease subtypes. MATERIALS AND METHODS. A retrospective review of patients with T-cell lymphomas who underwent PET/CT examination for initial disease staging or at disease relapse over a 5-year period was undertaken by correlation between a patient database and a PACS radiology information system. Disease subtypes were grouped according to World Health Organization categorization of mature natural killer cell-T-cell neoplasms. Sites of disease involvement were documented according to cutaneous or extranodal, nodal, and visceral locations. The maximum standardized uptake value (SUV) was recorded for each patient. RESULTS. One hundred thirty-five patients with T-cell lymphoma were included, and sites of disease were documented by use of FDG PET/CT in 122 (90%) patients. Of those 122 patients, 55 (45%) had cutaneous involvement, 95 (78%) had FDG-avid lymphadenopathy, and 54 (44%) had FDG-avid extranodal disease other than cutaneous involvement. A significant difference in maximum SUV was observed in cases of mycosis fungoides and mycosis fungoides with large cell transformation (SUV, 11.3 vs 3.8; p < 0.05). CONCLUSION. We found high rates of FDG positivity in T-cell lymphoma. Given the propensity for disease involvement outside the normal scan range of diagnostic CT, we recommend that patients with T-cell lymphoma be scanned from vertex to feet by use of PET/CT. © American Roentgen Ray Society.
Keywords: adult; aged; aged, 80 and over; middle aged; young adult; major clinical study; cancer localization; positron emission tomography; lymph node metastasis; sensitivity and specificity; radiopharmaceuticals; reproducibility of results; disease association; computer assisted tomography; image analysis; tomography, x-ray computed; data base; retrospective study; t cell lymphoma; lymphoma, t-cell; disease severity; diagnostic value; cell transformation; quantitative analysis; fluorodeoxyglucose f18; positron-emission tomography; cancer relapse; visceral metastasis; world health organization; cancer classification; t-cell lymphoma; fdg pet/ct; skin metastasis; mycosis fungoides; fluorodeoxyglucose; lymphadenopathy; nk t cell lymphoma; standardized uptake value; large cell transformation; subcutaneous panniculitis-like t-cell lymphoma
Journal Title: American Journal of Roentgenology
Volume: 195
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 2010-08-01
Start Page: 333
End Page: 340
Language: English
DOI: 10.2214/ajr.09.3665
PUBMED: 20651187
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: AJROA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Mithat Gonen
    932 Gonen
  2. John Noel Feeney
    8 Feeney
  3. Steven M Horwitz
    578 Horwitz
  4. Heiko Schoder
    477 Schoder