Authors: | Ballon, D.; Mahmood, U.; Jakubowski, A.; Koutcher, J. A. |
Article Title: | Resolution enhanced NMR spectroscopy in biological systems via magnetic susceptibility matched sample immersion chambers |
Abstract: | A technique is described which reduced the magnetic susceptibility induced line broadening in NMR spectra obtained from three biological systems at 4.7 Tesla. Proton spectra from a sealed suspension of HL60 leukemic myeioblasts yielded minimum linewidths of 1.3 Hz at 200 MHz (0.0065 ppm) after 10 min of automated shimming. 31 P spectra from an in vivo murine MCa mammary carcinoma yielded a well‐resolved phospharylcholine resonance without proton decoupling and with the resistive shim coil currents set to zero. 31 P spectra from a perfused suspension of RIF‐1 fibrosarcoma cells exhibited a γ‐nucleoside triphosphate resonance which was resolved into purine and pyrimidine components. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company |
Keywords: | human cell; nonhuman; animal cell; mouse; animal; mice; tumor cells, cultured; fibrosarcoma; image enhancement; breast carcinoma; magnetic resonance spectroscopy; cell suspension; phosphorus nuclear magnetic resonance; spectroscopy; nuclear magnetic resonance; proton nuclear magnetic resonance; in vivo; mammary neoplasms, experimental; magnetism; phosphorylcholine; mice, inbred c3h; susceptibility; nucleoside triphosphate; immersion; cell strain hl 60; human; article; leukemia, experimental; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
Journal Title: | Magnetic Resonance in Medicine |
Volume: | 30 |
Issue: | 6 |
ISSN: | 0740-3194 |
Publisher: | John Wiley & Sons |
Date Published: | 1993-12-01 |
Start Page: | 754 |
End Page: | 758 |
Language: | English |
DOI: | 10.1002/mrm.1910300615 |
PUBMED: | 8139459 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |