Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels Journal Article
| Authors: | Shukla-Dave, A.; Poptani, H.; Loevner, L. A.; Mancuso, A.; Serrai, H.; Rosenthal, D. I.; Kilger, A. M.; Nelson, D. S.; Zakian, K. L.; Arias-Mendoza, F.; Rijpkema, M.; Koutcher, J. A.; Brown, T. R.; Heerschap, A.; Glickson, J. D. |
| Article Title: | Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels |
| Abstract: | Rationale and Objectives. Combinations of chemotherapy and fractionated radiation therapy are the currently preferred nonsurgical treatment methods for squamous cell carcinoma of the head and neck, but to the authors' knowledge there is no reliable marker for predicting therapeutic response. Early identification of nonresponders would allow prompt replacement of ineffective, toxic therapy by alternative, potentially more effective procedures. Frequent regional node involvement facilitates surface coil investigation with phosphorus-31 magnetic resonance spectroscopy. Materials and Methods. P-31 magnetic resonance spectra were acquired from 12 patients before radiation therapy or chemotherapy. In vivo three-dimensional localized P-31 nuclear magnetic resonance chemical shift imaging was performed with a 1.5-T clinical imager and a dual-tuned H-1/P-31 surface coil. Proton decoupling and nuclear Overhauser enhancement were used to improve sensitivity and resolve overlapping signals in the phosphomonoester region of the spectrum. Results. The average pretreatment ratio of phosphomonoester to β-nucleoside triphosphate was significantly smaller in complete responders (n = 4) than in incomplete responders (partial responders plus nonresponders, n = 8) (0.0 ± 0.0 vs 1.22 ± 0.17 [P = .004]). Conclusion. Results of this preliminary study suggest that H- 1-decoupled P-31 magnetic resonance spectroscopy may prove to be a useful predictor of therapeutic response in head and neck cancers. © AUR, 2002. |
| Keywords: | adult; cancer chemotherapy; clinical article; treatment outcome; aged; middle aged; clinical trial; squamous cell carcinoma; carcinoma, squamous cell; multimodality cancer therapy; cancer radiotherapy; combined modality therapy; antineoplastic agent; sensitivity and specificity; prediction; chemistry; diagnostic agent; head and neck cancer; head and neck neoplasms; three dimensional imaging; multicenter study; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; nasopharynx tumor; nasopharyngeal neoplasms; phosphorus nuclear magnetic resonance; head and neck tumor; nucleoside; esters; ester; middle age; nucleosides; nuclear overhauser effect; humans; human; male; female; priority journal; article; magnetic resonance (mr), spectroscopy; support, u.s. gov't, p.h.s.; head and neck neoplasms, mr; head and neck neoplasms, therapy; magnetic resonance (mr), chemical shift |
| Journal Title: | Academic Radiology |
| Volume: | 9 |
| Issue: | 6 |
| ISSN: | 1076-6332 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2002-06-01 |
| Start Page: | 688 |
| End Page: | 694 |
| Language: | English |
| DOI: | 10.1016/s1076-6332(03)80314-8 |
| PUBMED: | 12061743 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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