Interleukin-1: Biological effects in human hematopoiesis Journal Article

  


Authors: Crown, J.; Jakubowski, A.; Gabrilove, J.
Article Title: Interleukin-1: Biological effects in human hematopoiesis
Abstract: Interleukin-1 (IL-1) produces many direct and indirect effects in hematopoiesis. IL-1 stimulates hematopoietic progenitors, and enhances production of other cytokines. Experimental data suggest a role in ameliorating the myelosuppression that occurs following cytotoxic chemotherapy. Recombinant human interleukin-1 has now entered clinical trial. We conducted a phase I trial of IL-1β alone, and following a myelosuppressive dose of 5-fluorouracil in patients with cancer. A prominent neutrophilia was noted within several hours, with a later, more sustained thrombocytosis. Hypotension was dose-limiting. We observed fewer days of neutropenia following 5-FU plus IL-1 compared to IL-1 alone, but the difference did not reach statistical significance. Early results from other investigators suggest a possible protective effect from chemotherapy-induced myelosuppression. Preclinical data suggest that combinations of IL-1 and lineage specific growth factors may produce synergistic hematologic effects. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords: clinical article; controlled study; human cell; fatigue; neutropenia; fluorouracil; hypertension; antineoplastic agents; chemotherapy; animal; pain; bone marrow; bone marrow suppression; nausea; tumor cells, cultured; stem cell; abdominal pain; fever; rash; hypotension; cytokine; cytokines; rigor; recombinant proteins; thrombocyte count; hematopoiesis; heartburn; headache; leukocyte count; phase 1 clinical trial; clinical trials; intravenous drug administration; thrombocytosis; interleukin 1; diaphoresis; interleukin-1; neutrophilia; breathing disorder; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; biological effects
Journal Title: Leukemia and Lymphoma
Volume: 9
Issue: 6
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 1993-01-01
Start Page: 433
End Page: 440
Language: English
DOI: 10.3109/10428199309145750
PUBMED: 8339049
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027261008&doi=10.3109%2f10428199309145750&partnerID=40&md5=a2f9d0154ea943160dfc5edbe8bc467c
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
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MSK Authors
  1. Ann Jakubowski
    455 Jakubowski
  2. Janice Gabrilove
    122 Gabrilove
  3. John Crown
    47 Crown
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