Whole body hyperthermia cytokine induction: A review, and unifying hypothesis for myeloprotection in the setting of cytotoxic therapy Journal Article
| Authors: | Katschinski, D. M.; Wiedemann, G. J.; Longo, W.; D'Oleire, F. R.; Spriggs, D.; Robins, H. I. |
| Article Title: | Whole body hyperthermia cytokine induction: A review, and unifying hypothesis for myeloprotection in the setting of cytotoxic therapy |
| Abstract: | Whole Body Hyperthermia (WBH) enhancement of chemotherapy and/or radiation without a concomitant increase in myelosuppression has been documented in clinical trials. We propose that the biological basis for this phenomena relates in part to the previously reported induction of peripheral cytokines by WBH, that is, granulocyte colony stimulating factor (G-CSF), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), and the regulatory cytokine IL-10. To further explain this myeloprotection and the additional clinical observation that WBH promotes early engraftment of bone marrow (when used as part of an allogenic bone marrow transplant preconditioning regimen) we developed a hypothesis: WBH increases peripheral IL-1β, IL-6, and TNF-α resulting in a secondary induction of IL-3 and granulocyte macrophage colony stimulating factor (GM-CSF) in the bone marrow, for which supportive data also exists. Taken collectively, these data provide an increased understanding of the biological sequelae of fever, as well as a testable unifying hypothesis, for future antineoplastic treatment strategies. |
| Keywords: | review; cancer adjuvant therapy; chemotherapy; neoplasm; neoplasms; metabolism; biological model; models, biological; bone marrow; bone marrow suppression; granulocyte macrophage colony stimulating factor; interleukin 10; interleukin 8; cytotoxicity; fever; cytokine; cytokines; tumor necrosis factor alpha; tumor necrosis factor-alpha; interleukin 6; cytokine production; hyperthermic therapy; bone marrow transplantation; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; cryoanesthesia; hypothermia, induced; tumor necrosis factor; bone marrow transplant; interleukin; colony stimulating factor; humans; human; whole body hyperthermia; interleukin 1 derivative |
| Journal Title: | Cytokine & Growth Factor Reviews |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 1359-6101 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1999-06-01 |
| Start Page: | 93 |
| End Page: | 97 |
| Language: | English |
| DOI: | 10.1016/s1359-6101(99)00006-4 |
| PUBMED: | 10743501 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
