Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies Journal Article

  

Authors:	Darnell, R. B.; DeAngelis, L. M.
Article Title:	Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies
Abstract:	We describe three patients with known or suspected small-cell lung cancer (SCLC), paraneoplastic neurological syndromes, and antineuronal antibodies who had unusually benign clinical courses. One patient survived 8 years free of disease and was positive for the anti-Hu antibody. A second patient survived 6 years after spontaneous tumour regression and had an atypical antineuronal antibody. A third patient with both the anti-Hu and atypical antineuronal antibody had spontaneous regression of a lung mass. All three patients had a subacute sensory neuropathy. Since paraneoplastic antineuronal antibodies also bind to tumour cells, these cases suggest that some (paraneoplastic) neurological syndromes without identifiable tumour may result from immune-mediated eradication of tumour cells. © 1993.
Keywords:	adult; aged; case report; cisplatin; follow up; sensory neuropathy; etoposide; lung neoplasms; cyclophosphamide; vincristine; immune response; lung carcinoma; antibodies; antibody detection; paraneoplastic syndrome; neurons, afferent; small cell carcinoma; carcinoma, small cell; middle age; nervous system diseases; paraneoplastic syndromes; neoplasm regression, spontaneous; human; male; female; priority journal; article; support, u.s. gov't, p.h.s.
Journal Title:	Lancet
Volume:	341
Issue:	8836
ISSN:	0140-6736
Publisher:	Elsevier Science, Inc.
Date Published:	1993-01-02
Start Page:	21
End Page:	22
Language:	English
DOI:	10.1016/0140-6736(93)92485-c
PUBMED:	8093269
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027514649&doi=10.1016%2f0140-6736%2893%2992485-C&partnerID=40&md5=7c6a99b3cdd2a563b2b81d3e0514db83
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/144225