Anhydroretlnol: A naturally occurring inhibitor of lymphocyte physiology Journal Article
| Authors: | Buck, J.; Grün, F.; Derguini, F.; Chen, Y.; Kimura, S.; Noy, N.; Hämmerling, U. |
| Article Title: | Anhydroretlnol: A naturally occurring inhibitor of lymphocyte physiology |
| Abstract: | Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HKR) a metabolite of retinol, has been implicated as the intraceUular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider $2. AK reversibly inhibits retinol- and 14-HKKdependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intraceUular signaling pathway blocked by AK in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506. © 1993, Rockefeller University Press., All rights reserved. |
| Keywords: | signal transduction; human cell; nonhuman; lymphocyte proliferation; t-lymphocytes; animal cell; interleukin 2; cell growth; b-lymphocytes; lymphocyte activation; drug mechanism; cell line, transformed; retinol; immunosuppressive treatment; cyclosporin a; tacrolimus; t lymphocyte activation; b lymphocyte differentiation; vitamin a; interleukin 2 receptor; calcineurin; retinol-binding proteins; retinol derivative; human; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 178 |
| Issue: | 2 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 1993-08-01 |
| Start Page: | 675 |
| End Page: | 680 |
| Language: | English |
| DOI: | 10.1084/jem.178.2.675 |
| PUBMED: | 8340762 |
| PROVIDER: | scopus |
| PMCID: | PMC2191109 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
