Intracellular signaling by 14-hydroxy-4,14-retro-retinol Journal Article

  


Authors: Buck, J.; Derguini, F.; Levi, E.; Nakanishi, K.; Hàˆmmerling, U.
Article Title: Intracellular signaling by 14-hydroxy-4,14-retro-retinol
Abstract: In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro- retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.
Keywords: signal transduction; unclassified drug; human cell; mouse; animal; mice; cell line; physiology; b lymphocyte; b-lymphocytes; chemistry; drug derivative; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; high performance liquid chromatography; retinol; retinoid; second messenger; growth substances; vitamin a; retinoids; lymphoblastoid cell; second messenger systems; spectrophotometry, ultraviolet; growth promotor; human; priority journal; article; ultraviolet spectrophotometry; support, u.s. gov't, p.h.s.; 14 hydroxy 4,14 retro retinol; 14-hydroxy-4,14-retro-retinol; 14 hydroxy 4,14 retroretinol
Journal Title: Science
Volume: 254
Issue: 5038
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 1991-12-13
Start Page: 1654
End Page: 1656
Language: English
DOI: 10.1126/science.1749937
PUBMED: 1749937
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026357656&doi=10.1126%2fscience.1749937&partnerID=40&md5=b5b0c17dc5b7d43c0f701cf36558c2ca
Notes: Source: Scopus
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MSK Authors
  1. Ulrich Hammerling
    79 Hammerling
  2. Ester Levi
    17 Levi
  3. Jochen Buck
    13 Buck
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