Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24 Journal Article


Authors: Bradley, J. F.; Rothberg, P. G.; Ladanyi, M.; Chaganti, R. S. K.
Article Title: Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24
Abstract: The sequence of the exon 1/intron 1 boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8;14) (q24;q32) and the other with t(8;22) (q24;q11). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding site in intron I, which is a frequent target for mutational inactivation in endemic Burkitt's lymphoma (eBL). The translocations at 8q24, and multiple mutations in the exon 1/intron 1 boundary region, are reminiscent of similar findings in eBL. The same underlying oncogenic event that occurs in most eBLs is thus found in some DLCLs. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
Keywords: controlled study; gene mutation; gene sequence; gene translocation; human cell; exon; mutation; intron; chromosomes, human, pair 8; molecular sequence data; genes, myc; base sequence; large cell lymphoma; chromosome 8; oligodeoxyribonucleotides; lymphoma, large-cell, diffuse; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics)
Journal Title: Genes Chromosomes and Cancer
Volume: 7
Issue: 3
ISSN: 1045-2257
Publisher: Wiley Periodicals, Inc  
Date Published: 1993-07-01
Start Page: 128
End Page: 130
Language: English
DOI: 10.1002/gcc.2870070303
PUBMED: 7687864
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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  1. Marc Ladanyi
    1328 Ladanyi
  2. Raju S K Chaganti
    391 Chaganti