Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24 Journal Article
| Authors: | Bradley, J. F.; Rothberg, P. G.; Ladanyi, M.; Chaganti, R. S. K. |
| Article Title: | Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24 |
| Abstract: | The sequence of the exon 1/intron 1 boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8;14) (q24;q32) and the other with t(8;22) (q24;q11). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding site in intron I, which is a frequent target for mutational inactivation in endemic Burkitt's lymphoma (eBL). The translocations at 8q24, and multiple mutations in the exon 1/intron 1 boundary region, are reminiscent of similar findings in eBL. The same underlying oncogenic event that occurs in most eBLs is thus found in some DLCLs. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | controlled study; gene mutation; gene sequence; gene translocation; human cell; exon; mutation; intron; chromosomes, human, pair 8; molecular sequence data; genes, myc; base sequence; large cell lymphoma; chromosome 8; oligodeoxyribonucleotides; lymphoma, large-cell, diffuse; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics) |
| Journal Title: | Genes Chromosomes and Cancer |
| Volume: | 7 |
| Issue: | 3 |
| ISSN: | 1045-2257 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 1993-07-01 |
| Start Page: | 128 |
| End Page: | 130 |
| Language: | English |
| DOI: | 10.1002/gcc.2870070303 |
| PUBMED: | 7687864 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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