Betaglycan presents ligand to the TGFβ signaling receptor Journal Article
| Authors: | López-Casillas, F.; Wrana, J. L.; Massagué, J. |
| Article Title: | Betaglycan presents ligand to the TGFβ signaling receptor |
| Abstract: | Transforming growth factor β (TGFβ) signals through a heteromeric protein kinase receptor that has a limited ability to bind ligand. This limitation is overcome by the action of betaglycan (TGFβ type III receptor), a separate TGFβ-binding membrane protein of previously unknown function. Betaglycan presents TGFβ directly to the kinase subunit of the signaling receptor, forming a high affinity ternary complex. Membrane betaglycan increases TGFβ binding to the signaling receptor, enhances cell responsiveness to TGFβ, and eliminates marked biological differences between TGFβ isoforms. Thus, betaglycan is a direct regulator of TGFβ access to the signaling receptors. © 1993. |
| Keywords: | signal transduction; binding affinity; models, biological; transforming growth factor beta; cell line; membrane proteins; amino acid sequence; molecular sequence data; bioassay; membrane protein; immunoprecipitation; receptors, transforming growth factor beta; ligands; base sequence; receptor affinity; protein kinase; ligand binding; phosphotransferases; fibroblast growth factor; receptor binding; membrane binding; cell surface receptor; receptors, cell surface; binding, competitive; cell receptor; proteoglycans; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Cell |
| Volume: | 73 |
| Issue: | 7 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 1993-07-02 |
| Start Page: | 1435 |
| End Page: | 1444 |
| Language: | English |
| DOI: | 10.1016/0092-8674(93)90368-z |
| PUBMED: | 8391934 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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