Potentiation of a three drug chemotherapy regimen by radiation Journal Article
| Authors: | Koutcher, J. A.; Alfieri, A. A.; Stolfi, R. L.; Devitt, M. L.; Colofiore, J. R.; Nord, L. D.; Martin, D. S. |
| Article Title: | Potentiation of a three drug chemotherapy regimen by radiation |
| Abstract: | The combination of N-(phosphonacetyl)-L-äspartate, 6-methylmercaptopurine, and 6-aminonicotinamide has been shown to be an effective antineoplastic regimen and also to enhance the effects of other chemotherapeutic agents. The mechanism of action of this combination of drugs is not known definitively, but one possible mechanism is biochemical modulation of energy metabolism and inhibition of production of tumor ATP. Tumor-bearing mice were treated with N-(phosphonacetyl)-L-äspartate, followed 17 h later by 6-methylmercaptopurine and 6-aminonicotinamide. 31P nuclear magnetic resonance spectroscopic studies demonstrated a significant depletion of high energy phosphates at 10 h post-6-methylmer-captopurine and 6-aminonicotinamide. The addition of radiation at this time was shown to induce a significantly longer tumor growth delay and a greater number of regressions (including durable complete regressions) than either chemotherapy or radiation alone. The combination of chemotherapy and radiation was found to be supra-additive compared to the antineoplastic effects of either modality administered separately, without a measurable increase in host toxicity. © 1993, American Association for Cancer Research. All rights reserved. |
| Keywords: | cancer chemotherapy; controlled study; drug efficacy; drug potentiation; nonhuman; cancer radiotherapy; combined modality therapy; mouse; animal; mice; antineoplastic combined chemotherapy protocols; animal experiment; animal model; combination chemotherapy; antineoplastic activity; tumor regression; mice, inbred balb c; cancer inhibition; neoplasms, experimental; neoplasm transplantation; energy metabolism; aspartic acid; growth inhibition; phosphonoacetic acid; 6-mercaptopurine; mice, inbred dba; sparfosic acid; 6 aminonicotinamide; female; priority journal; article; support, u.s. gov't, p.h.s.; 6 methylthioinosine; 6-aminonicotinamide |
| Journal Title: | Cancer Research |
| Volume: | 53 |
| Issue: | 15 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1993-08-01 |
| Start Page: | 3518 |
| End Page: | 3523 |
| Language: | English |
| PUBMED: | 8339257 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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