Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation Journal Article
| Authors: | Stolfi, R. L.; Colofiore, J. R.; Nord, L. D.; Martin, D. S. |
| Article Title: | Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation |
| Abstract: | A three-drug combination, PMA, consisting of (phosphonacetyl)-L-aspartic acid + 6-methylmercaptopurine riboside + 5-aminonicotinamide, preceding either 5-fluorouracil (5-FU) or adriamycin (Adr), produced tumor-regressing activity in a murine advanced breast tumor model not attainable with either 5-FU or Adr as single agents, or with any lesser combination of these drugs administered at maximally tolerated doses, Marked tumor-regressing activity was further increased significantly by using 5-FU and Adr together in conjunction with the modulatory biochemical conditioning (particularly ATP depletion) provided by pretreatment with PMA. |
| Keywords: | metabolism; 5-fluorouracil; injury; modulation; cell-death; polymerase; adriamycin; dna strand-breaks; murine breast-tumors |
| Journal Title: | Anti-Cancer Drugs |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 0959-4973 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1996-01-01 |
| Start Page: | 100 |
| End Page: | 104 |
| Language: | English |
| ACCESSION: | WOS:A1996UC78400012 |
| DOI: | 10.1097/00001813-199601000-00012 |
| PROVIDER: | wos |
| PUBMED: | 8742105 |
| Notes: | Article -- Source: Wos |
