On the relationship of ATP depletion to chemotherapeutically-induced tumor regression Journal Article
| Authors: | Colofiore, J. R.; Stolfi, R. L.; Nord, L. D.; Martin, D. S. |
| Article Title: | On the relationship of ATP depletion to chemotherapeutically-induced tumor regression |
| Abstract: | A positive correlation was found between increasing ATP depletion and enhanced tumor-regressing activity by combining PMA, a three drug combination (PALA, MMPR + 6-AN), with FUra, or Adria, or FUra + Adria. For example, at 48 h post treatment, ATP was 68% of saline controls with a 10% tumor regression rate (PMA); ATP was 55% with a 60% regression rate (PMA + FUra); ATP was 54% with an 80% regression rate (PMA + Adria); and ATP was 30% with a 100% regression rate (PMA + FUra + Adria). The results give support to the suggestion that ATP depletion may be a significant factor in the production of chemotherapeutically-induced apoptosis. |
| Keywords: | doxorubicin; fluorouracil; nonhuman; mouse; apoptosis; antineoplastic activity; tumor regression; adenosine triphosphate; sparfosic acid; 6 aminonicotinamide; female; priority journal; article; atp depletion; 6 methylthioinosine |
| Journal Title: | International Journal of Oncology |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 1019-6439 |
| Publisher: | Spandidos Publications |
| Date Published: | 1995-12-01 |
| Start Page: | 1401 |
| End Page: | 1404 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 21552979 |
| DOI: | 10.3892/ijo.7.6.1401 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
