Biochemical modulation of tumor cell energy IV. Evidence for the contribution of adenosine triphosphate (ATP) depletion to chemotherapeutically-induced tumor regression Journal Article
| Authors: | Colofiore, J. R.; Stolfi, R. L.; Dee Nord, L.; Martin, D. S. |
| Article Title: | Biochemical modulation of tumor cell energy IV. Evidence for the contribution of adenosine triphosphate (ATP) depletion to chemotherapeutically-induced tumor regression |
| Abstract: | DNA-damaging agents, e.g. Adriamycin® (ADR), are reported to cause tumor regression by induction of apoptosis. A reduction in the intracellular content of ATP is part of the biochemical cascade of events that ultimately results in programmed death of the cell, or apoptosis. A chemotherapeutic three-drug combination (PMA) consisting of N-(phosphonacetyl)-L-aspartate (PALA) + 6-methylmercaptopurine riboside (MMPR) + 6-aminonicotinamide (6AN) significantly lowers levels of ATP in CD8F1 murine breast tumors in vivo and produces tumor regression by apoptosis. Addition of the DNA-damaging antitumor agent ADR to PMA was found to further significantly deplete ATP in CD8F1 murine breast tumors in vivo with a concomitant significant increase in the number of tumor regressions. The correlative biochemical and therapeutic results are consistent with, and support, the hypothesis that ATP depletion is a significant factor and, therefore, is a worthy therapeutic target in the production of apoptosis. © 1995. |
| Keywords: | controlled study; doxorubicin; nonhuman; mouse; animals; mice; cell death; apoptosis; breast cancer; antineoplastic combined chemotherapy protocols; animal model; tumor regression; time factors; mice, inbred strains; neoplasm transplantation; adenosine triphosphate; aspartic acid; intravenous drug administration; phosphonoacetic acid; mammary neoplasms, animal; intraperitoneal drug administration; sparfosic acid; adriamycin; male; female; priority journal; article; methylthioinosine; 6 methylthioinosine; 6-aminonicotinamide |
| Journal Title: | Biochemical Pharmacology |
| Volume: | 50 |
| Issue: | 11 |
| ISSN: | 0006-2952 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1995-11-27 |
| Start Page: | 1943 |
| End Page: | 1948 |
| Language: | English |
| DOI: | 10.1016/0006-2952(95)02094-2 |
| PUBMED: | 8615876 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
