Fever among outpatients with advanced human immunodeficiency virus infection Journal Article


Authors: Sepkowitz, K. A.; Telzak, E. E.; Carrow, M.; Armstrong, D.
Article Title: Fever among outpatients with advanced human immunodeficiency virus infection
Abstract: Background: Fever is common among persons with human immunodeficiency virus (HIV) infection. However, the clinical implications of fever in this population have not been evaluated. We therefore undertook a prospective study of fever in persons with advanced HIV infection to determine the incidence and etiology of fever in this patient group. Methods: Prospective natural history study of 176 patients with advanced HIV infection followed up at Memorial Sloan-Kettering Cancer Center, New York, NY, from April 1, 1990, through December 31, 1990. Results: Fever occurred in 46% of patients. A diagnosis was made in 83% of episodes, with acquired immunodeficiency virus—defining illnesses accounting for half of the diagnosed cases. Patients whose conditions required more than 2 weeks to diagnose most often had lymphoma, Mycobacterium avium-intracellulare bacteremia, or Pneumocystis carinii pneumonia. Four patients had persistent unexplained fever without a clear source. Only one patient had fever that clearly responded to antiretroviral therapy. Conclusions: Fever is common among outpatients with advanced HIV infection. Human immunodeficiency virus itself is rarely the cause of fever in such patients; the cause of the fever should be thoroughly evaluated. © 1993, American Medical Association. All rights reserved.
Keywords: adult; major clinical study; human immunodeficiency virus infection; prospective studies; cohort studies; incidence; pneumocystis pneumonia; biopsy; fever; lymphoma; outpatient; bacteremia; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; cotrimoxazole; serology; dapsone; pentamidine; cytomegalovirus; infection risk; hiv infections; middle age; blood culture; aids-related opportunistic infections; outpatients; ceftazidime; retinitis; amoxicillin plus clavulanic acid; aids related complex; toxoplasma gondii; didanosine; human; male; female; priority journal; article; mycobacterium intracellulare avium; mycobacterium avium-intracellulare infection; support, u.s. gov't, p.h.s.; pneumonia, pneumocystis carinii
Journal Title: Archives of Internal Medicine
Volume: 153
Issue: 16
ISSN: 0003-9926
Publisher: American Medical Association  
Date Published: 1993-08-23
Start Page: 1909
End Page: 1912
Language: English
DOI: 10.1001/archinte.1993.00410160077006
PUBMED: 8250651
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Kent A Sepkowitz
    270 Sepkowitz
  2. Donald Armstrong
    222 Armstrong
  3. Melanie J Carrow
    7 Carrow