Increased incidence of cancer among homosexual men, New York City and San Francisco, 1978-1990 Journal Article


Authors: Koblin, B. A.; Hessol, N. A.; Zauber, A. G.; Taylor, P. E.; Buchbinder, S. P.; Katz, M. H.; Stevens, C. E.
Article Title: Increased incidence of cancer among homosexual men, New York City and San Francisco, 1978-1990
Abstract: Several studies have shown that human immunodeficiency virus type 1 (HIV-1) is associated with an increase in the incidence of Kaposi's sarcoma and non-Hodgkin's lymphoma among homosexual men. The role of HIV-1 in increasing the incidence of other malignancies is more controversial. The incidence of non-Kaposi's sarcoma cancer was examined from 1978 to 1990 among 15,565 homosexual men who participated in studies of hepatitis B virus infection in the late 1970s in New York City, New York, and San Francisco, California. The standardized incidence ratio (SIR) for all cancers was 1.6 (95% confidence interval (CI) 1.4-1.8). Excesses were observed for non- Hodgkin's lymphoma (SIR = 12.7; 95% CI 11.0-14.6), Hodgkin's disease (SIR = 2.5; 95% CI 1.5-3.9), and anal cancer (SIR = 24.2; 95% CI 13.5-39.9). As seen with non-Hodgkin's lymphoma, a cancer known to be associated with HIV-1, Hodgkin's disease incidence was significantly higher in more recent years compared with earlier years. No cases of Hodgkin's disease were found among HIV-1 antibody-negative men, and Hodgkin's disease was diagnosed near the time of initial acquired immunodeficiency syndrome diagnoses. Anal cancer incidence did not correlate with HIV-1 antibody status and did not tend to occur near the time of AIDS diagnoses. This study confirms the association of non-Hodgkin's lymphoma with HIV-1 infection and suggests an association between Hodgkin's disease and HIV-1 infection. An excess in anal cancer was observed but did not appear to be associated with HIV-1 infection.
Keywords: adult; cancer survival; major clinical study; united states; human immunodeficiency virus infection; cancer incidence; neoplasms; disease association; incidence; risk factors; cancer mortality; hodgkin disease; nonhodgkin lymphoma; lymphoma, non-hodgkin; new york city; homosexuality; homosexuality, male; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; anus cancer; migration; hiv; human immunodeficiency virus 1; hiv-1; anus neoplasms; hodgkin's disease; san francisco; humans; human; male; article; human immunodeficiency virus antibody; hiv-related lymphoma
Journal Title: American Journal of Epidemiology
Volume: 144
Issue: 10
ISSN: 0002-9262
Publisher: Oxford University Press  
Date Published: 1996-11-15
Start Page: 916
End Page: 923
Language: English
PUBMED: 8916502
PROVIDER: scopus
DOI: 10.1093/oxfordjournals.aje.a008861
DOI/URL:
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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  1. Ann G Zauber
    278 Zauber