Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk Journal Article
| Authors: | Beachler, D. C.; Gellert, L. L.; Jacobson, L. P.; Ambinder, R. F.; Breen, E. C.; Martínez-Maza, O.; Rabkin, C. C.; Kaslow, R. A.; D'Souza, G. |
| Article Title: | Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk |
| Abstract: | Kaposi sarcoma-associated herpes virus (KSHV) infects B-cells and is found in non-Hodgkin lymphoma (NHL) B-cell tumors and could therefore contribute to the occurrence of NHL. We performed a nested case-control study including 155 incident NHL cases and matched noncancer controls. Pre-NHL serum was tested for KSHV DNA and antibodies. Serum KSHV DNA was more common in cases than controls (14% versus 6%, P = 0.03), but after adjustment, the difference was not significant. Epstein-Barr virus serum DNA was similarly unassociated with NHL as were KSHV antibodies. KSHV is not a primary cause of NHL in HIV-infected men who have sex with men. © 2011 Lippincott Williams & Wilkins. |
| Keywords: | adult; controlled study; major clinical study; case control study; cancer risk; nonhuman; human immunodeficiency virus infection; cohort analysis; nonhodgkin lymphoma; dna; male homosexual; epstein barr virus; human herpesvirus 8; non-hodgkin lymphoma; aids cancer; kaposi sarcoma-associated herpesvirus; macs; virus dna |
| Journal Title: | JAIDS: Journal of Acquired Immune Deficiency Syndromes |
| Volume: | 56 |
| Issue: | 2 |
| ISSN: | 1525-4135 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2011-02-01 |
| Start Page: | 188 |
| End Page: | 192 |
| Language: | English |
| DOI: | 10.1097/QAI.0b013e3181ff976b |
| PROVIDER: | scopus |
| PMCID: | PMC3073851 |
| PUBMED: | 21116187 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 March 2011" - "CODEN: JJASF" - "Source: Scopus" |
