Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy Journal Article


Authors: Kusumoto, S.; Arcaini, L.; Hong, X.; Jin, J.; Kim, W. S.; Kwong, Y. L.; Peters, M. G.; Tanaka, Y.; Zelenetz, A. D.; Kuriki, H.; Fingerle-Rowson, G.; Nielsen, T.; Ueda, E.; Piper-Lepoutre, H.; Sellam, G.; Tobinai, K.
Article Title: Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy
Abstract: Risk of hepatitis B virus (HBV) reactivation was assessed in B-cell non-Hodgkin lymphoma (NHL) patients with resolved HBV infection (hepatitis B surface antigen negative, hepatitis B core antibody positive) who received obinutuzumab- or rituximab-containing immunochemotherapy in the phase 3 GOYA and GALLIUM studies. HBV DNA monitoring was undertaken monthly to 1 year after the last dose of study drug. In case of HBV reactivation (confirmed, HBV DNA ‡29 IU/mL), immunochemotherapy was withheld and nucleos(t)ide analog treatment (preemptive NAT) started. Immunochemotherapy was restarted if HBV DNA became undetectable or reactivation was not confirmed, and discontinued if HBV DNA exceeded 100 IU/mL on NAT. Prophylactic NAT was allowed by investigator discretion. Among 326 patients with resolved HBV infection, 27 (8.2%) had HBV reactivation, occurring a median of 125 days (interquartile range, 85-331 days) after the first dose. In 232 patients without prophylactic NAT, 25 (10.8%) had HBV reactivation; all received preemptive NAT. Ninety-four patients received prophylactic NAT; 2 (2.1%) had HBV reactivation. No patients developed HBV-related hepatitis. On multivariate Cox analysis, detectable HBV DNA at baseline was strongly associated with an increased risk of reactivation (adjusted hazard ratio [HR], 18.22; 95% confidence interval [CI], 6.04-54.93; P < .0001). Prophylactic NAT was strongly associated with a reduced risk (adjusted HR, 0.09; 95% CI, 0.02-0.41; P 5 .0018). HBV DNA monitoring–guided preemptive NAT was effective in preventing HBV-related hepatitis during anti–CD20-containing immunochemotherapy in B-cell NHL patients with resolved HBV infection. Antiviral prophylaxis was also effective and may be appropriate for high-risk patients. These trials were registered at www. clinicaltrials.gov as NCT01287741 (GOYA) and NCT01332968 (GALLIUM). © 2019 by The American Society of Hematology.
Journal Title: Blood
Volume: 133
Issue: 2
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2019-01-10
Start Page: 137
End Page: 146
Language: English
DOI: 10.1182/blood-2018-04-848044
PUBMED: 30341058
PROVIDER: scopus
PMCID: PMC6337873
DOI/URL:
Notes: Article -- Export Date: 1 February 2019 -- Source: Scopus
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MSK Authors
  1. Andrew D Zelenetz
    539 Zelenetz