Molecular pathology of thyroid cancer: Diagnostic and clinical implications Journal Article
| Authors: | Fagin, J. A.; Mitsiades, N. |
| Article Title: | Molecular pathology of thyroid cancer: Diagnostic and clinical implications |
| Abstract: | There is now a reasonably good understanding of the key oncogenic events involved in the initiation and progression of thyroid cancer. Many of these are characteristic of certain tumor types, and their presence conveys diagnostic and prognostic information. It is not yet clear how this information will be applied to clinical practice. Based on preclinical evidence, mutations of genes encoding certain kinases may also predict response to specific tyrosine kinase inhibitors, although this has not yet been explored systematically in clinical trials. © 2008 Elsevier Ltd. All rights reserved. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein expression; pathogenesis; review; erlotinib; nonhuman; treatment planning; molecular genetics; preoperative evaluation; protein function; protein analysis; gene overexpression; lung non small cell cancer; tumor differentiation; mutational analysis; phosphatidylinositol 3 kinase; protein p53; oncocytoma; carcinogenesis; oncogene; gene rearrangement; drug response; 1-phosphatidylinositol 3-kinase; pten phosphohydrolase; gefitinib; ras protein; thyroid cancer; thyroid neoplasms; ras proteins; pten; beta catenin; peroxisome proliferator activated receptor gamma; thyroid papillary carcinoma; protein ret; proto-oncogene proteins c-ret; b raf kinase; braf; ras; phosphotransferase inhibitor; apc protein; cytopathology; anaplastic carcinoma; proto-oncogene proteins b-raf; genetic polymorphism; carcinoma, papillary, follicular; thyroid follicular carcinoma; transcription factor pax8; protein patched; molecular diagnostics; pi3 kinase; ret |
| Journal Title: | Best Practice and Research: Clinical Endocrinology and Metabolism |
| Volume: | 22 |
| Issue: | 6 |
| ISSN: | 1521-690X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-12-01 |
| Start Page: | 955 |
| End Page: | 969 |
| Language: | English |
| DOI: | 10.1016/j.beem.2008.09.017 |
| PUBMED: | 19041825 |
| PROVIDER: | scopus |
| PMCID: | PMC2615540 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 26" - "Export Date: 17 November 2011" - "CODEN: BPRCE" - "Source: Scopus" |
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