Induced differentiation of erythroleukemia cells by hexamethylene bisacetamide: A model for cytodifferentiation of transformed cells Journal Article

   

Authors:	Marks, P. A.; Rifkind, R. A.
Article Title:	Induced differentiation of erythroleukemia cells by hexamethylene bisacetamide: A model for cytodifferentiation of transformed cells
Abstract:	There is considerable evidence that malignant transformation need not eliminate the potential for a cell to express its developmental capabilities. This review explores the process whereby polar compounds, hexamethylene bisacetamide (HMBA) in particular, induce murine erythroid leukemoid cells (MEL) to express the differentiated erythroid phenotype, including hemoglobin production and cessation of cell division. This is a multi-step process which, although the mechanisms of action of HMBA are not yet fully understood, is amenable to experimental definition and analysis. Early effects, including changes in protein kinase C activity, in ion transport, and in expression of certain nuclear proto-oncogenes, have been examined in relation to the onset of terminal cell differentiation. This experimental experience has formed the context for initiating preliminary clinical studies designed to examine the pharmacology of HMBA and to explore its potential for modifying the natural history of cancer.
Keywords:	nonhuman; animal cell; phenotype; proto oncogene; gene expression; cell differentiation; animalia; cell culture; cell transformation; globin gene; murinae; phase 1 clinical trial; drug therapy; protein kinase; book; ion transport; hexamethylenebisacetamide; human; erythroleukemia cell
Journal Title:	Environmental Health Perspectives
Volume:	80
ISSN:	0091-6765
Publisher:	US Department of Health and Human Services
Date Published:	1989-03-01
Start Page:	181
End Page:	188
Language:	English
DOI:	10.1289/ehp.8980181
PUBMED:	2647479
PROVIDER:	scopus
PMCID:	PMC1567625
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024520626&doi=10.1289%2fehp.8980181&partnerID=40&md5=b2f1416c289fdffcbaf708413369ad11
Notes:	Review -- Export Date: 14 April 2020 -- Source: Scopus

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