Molecular targets on the horizon for kidney and urothelial cancer Journal Article


Authors: Bellmunt, J.; Teh, B. T.; Tortora, G.; Rosenberg, J. E.
Article Title: Molecular targets on the horizon for kidney and urothelial cancer
Abstract: As whole-genome sequencing technology rapidly advances, the insights gained from deciphering cancer genomes are shifting the paradigm in the diagnosis and treatment of cancer with the promise of individualized treatment for each patient. Information gained in this way is extensive for certain cancers, but fairly limited in renal cell carcinomas and urothelial carcinoma. Mutations in multiple, potentially druggable genes have been identified in urothelial carcinomas; however, the association between molecular alterations and clinical outcome has not yet been robustly demonstrated. Data in this area are emerging in renal cell carcinoma, leading to the development of targeted agents that have improved overall survival. Unfortunately, these treatments rarely yield complete responses, are not curative, and development of resistance ensues. This Review will focus on the biology of non-hormonally driven urological cancers. We discuss how approaches using whole-genome sequencing can facilitate the discovery of biomarkers of drug sensitivity in both renal cell carcinomas and urothelial carcinomas. For renal cell carcinomas, we will describe how genomic and epigenomic mining has uncovered novel genes and pathways involved in tumorigenesis, tumour classification and mechanisms of resistance in the various subsets of this disease and the potential for exploiting these discoveries in the clinic. © 2013 Macmillan Publishers Limited.
Journal Title: Nature Reviews Clinical Oncology
Volume: 10
Issue: 10
ISSN: 1759-4774
Publisher: Nature Publishing Group  
Date Published: 2013-10-01
Start Page: 557
End Page: 570
Language: English
DOI: 10.1038/nrclinonc.2013.155
PROVIDER: scopus
PUBMED: 23982523
DOI/URL:
Notes: --- - "Export Date: 1 November 2013" - "Source: Scopus"
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  1. Jonathan Eric Rosenberg
    513 Rosenberg