Platinum resistance and impaired survival in patients with advanced primary peritoneal carcinoma: matched-case comparison with patients with epithelial ovarian carcinoma Journal Article

  

Authors:	Eisenhauer, E. L.; Sonoda, Y.; Levine, D. A.; Abu-Rustum, N. R.; Gemignani, M. L.; Sabbatini, P. J.; Barakat, R. R.; Chi, D. S.
Article Title:	Platinum resistance and impaired survival in patients with advanced primary peritoneal carcinoma: matched-case comparison with patients with epithelial ovarian carcinoma
Abstract:	Objective: The objective of the study was to compare chemotherapy response and survival of patients with advanced primary peritoneal carcinoma (PPC) vs those with epithelial ovarian carcinoma (EOC). Study Design: From 1998 to 2004, 43 PPC patients were identified and matched to 129 patients with International Federation of Gynecology and Obstetrics stage IIIC-IV EOC by criteria abstracted from medical records. Primary endpoints were chemotherapy response, platinum resistance, progression-free survival (PFS), and overall survival (OS). Results: All patients received primary platinum-taxane chemotherapy. There was no significant difference in achieving a clinical complete response. PPC patients were more likely to be platinum resistant at 6 months and had significantly impaired PFS and OS. After multivariate analysis, PPC was independently associated with a worse prognosis for both survival endpoints. Conclusion: PPC was associated with a similar initial response but a higher rate of platinum resistance and shorter PFS and OS. Consideration of these results may be useful for patient counseling, trial stratification, and molecular comparisons. © 2008 Mosby, Inc. All rights reserved.
Keywords:	survival; adult; cancer chemotherapy; cancer survival; controlled study; treatment response; aged; aged, 80 and over; disease-free survival; middle aged; survival analysis; major clinical study; overall survival; case control study; case-control studies; advanced cancer; antineoplastic agents; united states; cancer patient; comparative study; combined modality therapy; neoplasm staging; prospective studies; ovarian cancer; ovarian neoplasms; multiple cycle treatment; peritoneum cancer; neoplasm recurrence, local; peritoneal neoplasms; drug resistance, neoplasm; medical record review; cancer resistance; ovary carcinoma; multivariate analysis; platinum derivative; taxoids; taxane derivative; databases, factual; bridged compounds; primary peritoneal
Journal Title:	American Journal of Obstetrics and Gynecology
Volume:	198
Issue:	2
ISSN:	0002-9378
Publisher:	Elsevier Inc.
Date Published:	2008-02-01
Start Page:	213.e1
End Page:	213.e7
Language:	English
DOI:	10.1016/j.ajog.2007.07.003
PUBMED:	18226627
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-38349129174&partnerID=40&md5=0b640cbdca46450bda4985149002dc6d
Notes:	--- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: AJOGA" - "Source: Scopus"

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