An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debulking surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant chemotherapy (NACT) Journal Article

  

Authors:	Chi, D. S.; Musa, F.; Dao, F.; Zivanovic, O.; Sonoda, Y.; Leitao, M. M.; Levine, D. A.; Gardner, G. J.; Abu-Rustum, N. R.; Barakat, R. R.
Article Title:	An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debulking surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant chemotherapy (NACT)
Abstract:	Objective: The recent EORTC-NCIC randomized trial comparing primary debulking surgery (PDS) to neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian carcinoma (EOC) reported a median progression-free survival (PFS) of 12 months and overall survival (OS) of 30 months for both arms. Due to the equivalent survival and decreased morbidity with NACT, many now consider it the preferred approach. We analyzed the outcomes of patients treated with PDS at our institution during the same time period in which the EORTC-NCIC trial was conducted, using identical inclusion criteria. Methods: We identified all patients undergoing primary treatment for advanced EOC at our institution from 9/98-12/06. Study inclusion and exclusion criteria were identical to those of the EORTC-NCIC trial. Standard statistical tests were used. Results: Of 316 eligible patients, 285 (90%) underwent PDS and 31 (10%) received NACT due to extra-abdominal disease, medical comorbidities, and/or advanced age (> 85 years). Of the 285 patients who underwent PDS, most had carcinoma of ovarian origin (248, 87%); stage IIIC disease (249, 87%); grade 3 tumors (237, 83%); and serous histology (249, 87%). Optimal cytoreduction (≤ 1 cm residual) was achieved in 203 patients (71%). Postoperative platinum-based chemotherapy was given to 281 of 285 patients (99%). The median PFS and OS were 17 and 50 months, respectively. Conclusion: PDS should continue to be the preferred initial management for patients with bulky stages IIIC-IV ovarian carcinoma. NACT should be reserved for those who cannot tolerate PDS and/or for whom optimal cytoreduction is not feasible. © 2011 Elsevier Inc. All rights reserved.
Keywords:	adult; cancer survival; controlled study; treatment outcome; aged; major clinical study; overall survival; histopathology; advanced cancer; cancer adjuvant therapy; cancer patient; cancer staging; analysis; ovarian cancer; cytoreductive surgery; progression free survival; ovary cancer; peritoneum cancer; randomized controlled trial; morbidity; comorbidity; neoadjuvant chemotherapy; cytoreduction; uterine tube carcinoma; fallopian tube cancer; primary peritoneal cancer; comparative effectiveness; primary debulking surgery; epithelial ovarian carcinoma
Journal Title:	Gynecologic Oncology
Volume:	124
Issue:	1
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2012-01-01
Start Page:	10
End Page:	14
Language:	English
DOI:	10.1016/j.ygyno.2011.08.014
PROVIDER:	scopus
PUBMED:	21917306
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-83055181259&partnerID=40&md5=d56ff15c45546a31b3eb705853a2905b
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 3 January 2012" - "CODEN: GYNOA" - "Source: Scopus"

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