Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: A randomized controlled study Journal Article


Authors: Deng, G.; Hou, B. L.; Holodny, A. I.; Cassileth, B. R.
Article Title: Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: A randomized controlled study
Abstract: Background: Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. Methods: In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured. Results: Unilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nor deactivation. True acupuncture induced more saliva production than sham acupuncture. Conclusion: Acupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production. © 2008 Deng et al; licensee BioMed Central Ltd.
Keywords: adult; controlled study; clinical trial; nuclear magnetic resonance imaging; methodology; magnetic resonance imaging; controlled clinical trial; image analysis; randomized controlled trial; brain cortex; correlation analysis; reference values; xerostomia; acupuncture; randomization; functional magnetic resonance imaging; parotid gland; brain region; normal human; sham procedure; secretion; nerve stimulation; human experiment; reference value; acupuncture therapy; saliva; salivation; acupuncture points
Journal Title: BMC Complementary and Alternative Medicine
Volume: 8
ISSN: 1472-6882
Publisher: Biomed Central Ltd  
Date Published: 2008-07-07
Start Page: 37
Language: English
DOI: 10.1186/1472-6882-8-37
PUBMED: 18606019
PROVIDER: scopus
PMCID: PMC2474572
DOI/URL:
Notes: --- - "Cited By (since 1996): 17" - "Export Date: 17 November 2011" - "CODEN: BCAMC" - "Source: Scopus"
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MSK Authors
  1. Barrie R Cassileth
    189 Cassileth
  2. Bob L Hou
    22 Hou
  3. Gary E Deng
    52 Deng
  4. Andrei Holodny
    136 Holodny