A phase II, randomized, controlled trial of acupuncture for reduction of postcolectomy ileus Journal Article


Authors: Deng, G.; Wong, W. D.; Guillem, J.; Chan, Y.; Affuso, T.; Yeung, K. S.; Coleton, M.; Sjoberg, D.; Vickers, A.; Cassileth, B.
Article Title: A phase II, randomized, controlled trial of acupuncture for reduction of postcolectomy ileus
Abstract: Purpose: Postoperative ileus (POI) prolongs hospital stay and increases risk of postoperative complications. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture reduces POI more effectively than sham acupuncture. Methods: Colon cancer patients undergoing elective colectomy were randomized to receive 30 min of true or sham acupuncture twice daily during their first 3 postoperative days. GI-3 (the later of the following two events: time that the patient first tolerated solid food, AND time that the patient first passed flatus OR a bowel movement) and GI-2 (the later of the following two events: time patient first tolerated solid food AND time patient first passed a bowel movement) were determined. Pain, nausea, vomiting, and use of pain medications were evaluated daily for the first 3 postoperative days. Results: Ninety patients were randomized. Eighty-one received the allocated intervention: 39 in the true acupuncture group and 42 in the sham acupuncture group, all evaluated for the primary endpoint. The mean time to GI-3 was 149 h [standard deviation (SD) 71 h] and 146 (SD 62 h) after surgery for the acupuncture group and the sham acupuncture group (difference between means -2 h; 95 % confidence interval -31, 26; p = 0.9). No significant differences were found between groups for secondary endpoints. Conclusions: True acupuncture as provided in this study did not reduce POI more significantly than sham acupuncture. The study was limited by a standard deviation much larger than expected, suggesting that a study with a larger sample size might be required. © 2012 Society of Surgical Oncology.
Keywords: adult; controlled study; middle aged; survival rate; major clinical study; postoperative period; conference paper; postoperative care; outcome assessment; follow-up studies; neoplasm staging; prospective studies; colorectal cancer; randomized controlled trial; colonic neoplasms; postoperative complications; length of stay; colon resection; antiemetic agent; acupuncture; ileus; postoperative pain; analgesic agent; sham procedure; sample size; elective surgery; colectomy; single blind procedure; intervention studies; postoperative nausea; postoperative ileus; postoperative vomiting
Journal Title: Annals of Surgical Oncology
Volume: 20
Issue: 4
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2013-04-01
Start Page: 1164
End Page: 1169
Language: English
DOI: 10.1245/s10434-012-2759-7
PROVIDER: scopus
PUBMED: 23188543
PMCID: PMC3978767
DOI/URL:
Notes: --- - "Export Date: 1 April 2013" - "CODEN: ASONF" - "Source: Scopus"
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MSK Authors
  1. Barrie R Cassileth
    198 Cassileth
  2. Jose Guillem
    404 Guillem
  3. Gary E Deng
    66 Deng
  4. Andrew J Vickers
    677 Vickers
  5. Daniel D. Sjoberg
    189 Sjoberg
  6. Douglas W Wong
    177 Wong
  7. Kwokwai Yeung
    36 Yeung
  8. Yi Hung Chan
    5 Chan
  9. Theresa Affuso
    1 Affuso